Choroid plexus: Insights from distinct epithelial cellular components

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Opinion in Neurobiology Pub Date : 2025-04-22 DOI:10.1016/j.conb.2025.103028

Valentina Scarpetta , Kim Hoa Ho , Marleen Trapp , Annarita Patrizi

引用次数: 0

Abstract

The choroid plexus (ChP) serves as a vital interface between blood and cerebrospinal fluid (CSF), playing a pivotal role in central nervous system (CNS) development and communication with the body. This review mainly summarizes how the ChP epithelial cells respond to physiological and pathological stimuli, emphasizing the role of distinct organelles and key molecular signaling pathways. Additionally, we discuss the roles of ChP cilia, an evolutionary conserved organelle whose function is still under investigation. Understanding these processes is essential for elucidating how ChP function modulates intrinsic and extrinsic stimuli, which are crucial for maintaining CNS and body homeostasis.

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脉络膜丛：来自不同上皮细胞成分的见解

脉络膜丛（ChP）是血液和脑脊液（CSF）之间的重要接口，在中枢神经系统（CNS）的发育和与身体的交流中起着关键作用。本文主要综述了ChP上皮细胞对生理和病理刺激的反应，强调了不同细胞器和关键分子信号通路的作用。此外，我们还讨论了ChP纤毛的作用，这是一种进化保守的细胞器，其功能仍在研究中。了解这些过程对于阐明ChP功能如何调节内在和外在刺激是至关重要的，这对于维持中枢神经系统和身体的稳态至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Neurobiology 医学-神经科学

CiteScore

11.10

自引率

1.80%

发文量

130

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience