Exploring genes related to impaired insulin secretion and the interaction with diet in type 2 diabetes mellitus: A scoping review of observational studies

Q2 Medicine

Obesity Medicine Pub Date : 2025-04-17 DOI:10.1016/j.obmed.2025.100611

Rambu L.N.K.R. Triandhini , Ahmad Hamim Sadewa , Siti Helmiyati

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引用次数: 0

Abstract

Diabetes mellitus is a metabolic disorder and a major global health concern. This scoping review aimed to systematically map current data that describe the relationship between genetic variant interactions related to insulin secretion and diet with the incidence of type 2 diabetes mellitus. A literature search was conducted through PubMed, Cochrane, EBSCO, ProQuest, and hand searching. Thirteen eligible articles were obtained from 1375 searches in the database; TCF7L2 variants were the most frequently examined and demonstrated interactions with fiber, followed by the CDKAL1 gene variant, which showed interactions mainly with dietary components, such as fats, proteins, and coffee. Statistically significant findings were also reported for IGFBP2, NOTCH2, KCNJ11, GIPR, HFE, and ZBED3 variants. Nevertheless, most of these studies are yet to be replicated, and some findings indicated inconsistencies. Gene interactions related to insulin secretion and diet play important roles in the risk of type 2 diabetes, although further research is required to validate these findings.

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探索与2型糖尿病胰岛素分泌受损及其与饮食相互作用相关的基因：一项观察性研究的范围综述

糖尿病是一种代谢紊乱，是一个主要的全球健康问题。本综述旨在系统地绘制当前数据，描述与胰岛素分泌和饮食相关的遗传变异相互作用与2型糖尿病发病率之间的关系。通过PubMed、Cochrane、EBSCO、ProQuest和手工检索进行文献检索。从数据库的1375次检索中获得13篇符合条件的文章；TCF7L2变异是最常被检测到的，并显示出与纤维的相互作用，其次是CDKAL1基因变异，主要显示出与饮食成分（如脂肪、蛋白质和咖啡）的相互作用。IGFBP2、NOTCH2、KCNJ11、GIPR、HFE和ZBED3变异也有统计学意义的发现。然而，这些研究中的大多数还有待重复，一些研究结果表明不一致。与胰岛素分泌和饮食相关的基因相互作用在2型糖尿病的风险中起着重要作用，尽管需要进一步的研究来验证这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.