A multifunctional nanoplatform based on chlorin e6 for fluorescence imaging-guided sonodynamic and chemodynamic cancer therapy

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-04-21 DOI:10.1016/j.colsurfb.2025.114718

Qi Xu , Fang He , Zhimin Mo , Han Hu , Qianyuan He , Zushun Xu , Shengli Yang , Xiaojuan Qin

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引用次数: 0

Abstract

Emerging multimodal therapy strategies based on sonodynamic therapy (SDT) are foreseen as foundational in forthcoming tumor theranostics. Nevertheless, the therapeutic effects of SDT are limited by the hypoxic environment of the tumor microenvironment (TME). Based on this, nano-enzymes are envisioned to decompose excess hydrogen peroxide in the tumor microenvironment to generate oxygen. Here, PEG-PLGA-coated CeO₂ nanoparticles loaded with the sonosensitizer chlorin e6 (CC@PP) were prepared for cancer therapy based on a nanoprecipitation method. CC@PP possesses highly efficient catalase-like (CAT) properties, which are able to decompose overexpressed H₂O₂ into O₂ and enhance the effect of O₂-dependent sonodynamic therapy. In addition, it can act as a peroxidase (POD) at lower pH for chemodynamic therapy. Under the guidance of the US, CC@PP can perform synergistic sonodynamic and chemodynamic cancer therapy and inhibit tumor growth efficiently, CC@PP is biocompatible, has good in vivo fluorescence imaging effect, and has integrated diagnostic and therapeutic properties, which can be effectively aggregated at the tumor area. In this study, the effect of sonodynamic therapy was enhanced by improving the hypoxic environment in the TME, and multimodal synergistic enhancement of cancer therapy was realized.

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基于氯e6的多功能纳米平台用于荧光成像引导声动力和化学动力癌症治疗

基于声动力治疗（SDT）的新兴多模式治疗策略被认为是未来肿瘤治疗的基础。然而，SDT的治疗效果受到肿瘤微环境（TME）缺氧环境的限制。基于此，纳米酶有望分解肿瘤微环境中过量的过氧化氢生成氧气。本研究利用纳米沉淀法制备了负载声敏剂氯e6 （CC@PP）的peg - plga包覆的CeO2纳米颗粒，用于癌症治疗。CC@PP具有高效的过氧化氢酶样（CAT）特性，能够将过表达的H2O2分解为O2，增强O2依赖性声动力治疗的效果。此外，它还可以在低pH下作为过氧化物酶（POD）进行化学动力学治疗。在美国的指导下，CC@PP可以进行声动力和化学动力的协同癌症治疗，有效抑制肿瘤生长，CC@PP具有生物相容性，具有良好的体内荧光成像效果，具有综合诊断和治疗特性，可以有效地聚集在肿瘤区域。本研究通过改善TME缺氧环境增强声动力治疗效果，实现多模式协同增强肿瘤治疗。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.