Transcriptional expression analysis of fosfomycin resistance determinants in Escherichia coli with MDR trait

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2025-04-21 DOI:10.1016/j.ijmmb.2025.100859

Jayalaxmi Wangkheimayum , Ng Lakhitombi Chanu , Debadatta Dhar Chanda , Amitabha Bhattacharjee

引用次数: 0

Abstract

Fosfomycin is a therapeutic alternative for urinary tract infection (UTI). Escherichia coli produces fosfomycin modifying enzymes (fos genes) that is the contributor for resistance to this group of antimicrobials. The current research work characterizes fosfomycin resistance determinants in Escherichia coli and their transferability. Fosfomycin modifying enzyme genes were found to be carried within a plasmid of inc type FIC. Under subinhibitory concentration of fosfomycin, transcriptional expression revealed upregulation for fosA10, fosA8, fosA, and fosA2.The current study emphasizes the necessity of ongoing surveillance of E. coli resistance patterns and transmission dynamics, particularly regards to fosfomycin, to implement the best possible treatment strategy.

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耐多药大肠杆菌中磷霉素耐药决定因素的转录表达分析

磷霉素是治疗尿路感染（UTI）的一种替代方法。大肠杆菌产生磷霉素修饰酶（fos基因），这是对这组抗菌素产生耐药性的原因。目前的研究工作表征了大肠杆菌中磷霉素耐药决定因素及其可转移性。发现磷霉素修饰酶基因在inc型FIC的质粒内携带。在磷霉素亚抑制浓度下，fosA10、fosA8、fosA和fosA2转录表达上调。目前的研究强调有必要持续监测大肠杆菌的耐药模式和传播动态，特别是关于磷霉素，以实施最佳的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.