Air pollution and cardiovascular disease: a systematic review of the effects of air pollution, including bushfire smoke, on cardiovascular disease

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Fariha Islam, Sai Keerthana Nukala, Pallavi Shrestha, Tim Badgery-Parker, Fiona Foo
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引用次数: 0

Abstract

Objective

Particulate matter (PM) with diameter ≤ 2.5 μm (PM2.5) and ≤ 10 μm (PM10), including from bushfire smoke, is associated with cardiovascular disease (CVD) morbidity and mortality. This systematic review assesses how CVD morbidity and mortality is affected by type, duration, and level of air pollution exposure.

Data sources

A search was conducted on Ovid Medline, Embase and Scopus, spanning across 1 January 2012 to 30 July 2022. Primary quantitative studies exploring the effect of PM2.5, PM10 or bushfire smoke on CVD were included. Studies without adjustment for confounding factors were excluded. The Newcastle-Ottawa Scale was used to assess the risk of bias (ROB) in the studies, and meta-analysis was conducted on relevant outcomes.

Findings

A total 275 studies were obtained, and 80 studies were analysed with diseases ranging from ICD-10 I00-I99. For CVD morbidity, increased PM2.5 and PM10 was associated with 1.92 (95 % CI: 0.58,3.26) years of life lost per 10 μg/m3 increase in exposure. Increased PM2.5 and PM10 was associated with a 0.52 % (95 % CI: 0.37,0.68) increase in mortality per 10 μg/m3 increase in exposure. Bushfire smoke also presented similar trends. Two studies had high ROB, 42 had medium ROB, and 36 had low ROB. There was high heterogeneity between the studies, with I2 values ranging between 88.09 % and 94.25 %.

Conclusion

Air pollution including bushfire smoke is associated with increased CVD morbidity and mortality. This effect ranges across different types, durations, and levels of air pollution exposure, making stringent climate change and air pollution mitigation strategies imperative.

Abstract Image

空气污染与心血管疾病:对空气污染(包括森林大火烟雾)对心血管疾病影响的系统回顾
目的:直径≤2.5 μm (PM2.5)和≤10 μm (PM10)的颗粒物(PM),包括来自森林大火烟雾的颗粒物,与心血管疾病(CVD)的发病率和死亡率相关。本系统综述评估了心血管疾病发病率和死亡率如何受到空气污染暴露类型、持续时间和水平的影响。数据来源在Ovid Medline, Embase和Scopus上进行了搜索,时间跨度为2012年1月1日至2022年7月30日。初步的定量研究探讨了PM2.5、PM10或森林大火烟雾对心血管疾病的影响。未调整混杂因素的研究被排除在外。采用纽卡斯尔-渥太华量表评估研究的偏倚风险(ROB),并对相关结果进行meta分析。共获得275项研究,分析了80项研究,疾病范围从icd - 100 - 99。对于心血管疾病的发病率,PM2.5和PM10的增加与每增加10 μg/m3的暴露量减少1.92年(95% CI: 0.58,3.26)相关。PM2.5和PM10的增加与每10 μg/m3暴露增加0.52% (95% CI: 0.37,0.68)的死亡率相关。森林大火的烟雾也呈现出类似的趋势。2项研究有高的ROB, 42项研究有中等的ROB, 36项研究有低的ROB。研究间存在高度异质性,I2值在88.09% ~ 94.25%之间。结论包括森林火灾烟雾在内的大气污染与心血管疾病发病率和死亡率升高有关。这种影响涉及不同类型、持续时间和接触空气污染的程度,因此必须采取严格的气候变化和空气污染缓解战略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
1.60
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