A Copper Paradodecatungstate-B Compound Decorated by Glycine Ligand: Synthesis, Structure, and Anticancer Activities

IF 4.3 2区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Pub Date : 2025-04-22 DOI:10.1021/acs.inorgchem.5c00564

Yi Liu, Xinyuan Liu, Wenhui Chang, Hanzhi Zhang, Qiqi Zhang, Yi Liu, Xinyuan Jiang, Li Tao, Cheng Ma, Lu-Nan Zhang, Yongge Wei, Lubin Ni

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Abstract

In this study, a polyoxometalate-based inorganic–organic hybrid material, Na₄[Cu₄(Gly)₂(HGly)₂(H₄W₁₂O₄₂)]Cl₂·20H₂O (1) (Gly = glycine), was synthesized via a self-assembly approach by incorporating copper ions and glycine into the paradodecatungstate anion [H₄W₁₂O₄₂]^8–. The structure and properties of compound 1 were systematically characterized using single crystal X-ray diffraction, elemental analysis, powder X-ray diffraction, FTIR, Raman spectroscopy, cyclic voltammetry (CV), and UV–vis spectroscopy. Additionally, its anticancer activity was evaluated in vitro against human liver cancer cells (HepG2) and human renal epithelial cells (HEK293T) using the MTT assay, yielding an IC₅₀ value of 36.232 ± 0.41 μM. The findings demonstrate that compound 1 effectively inhibits the proliferation of liver cancer cells, highlighting its potential as a candidate for polyoxotungstate (POT)-based anticancer drug development.

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甘氨酸配体修饰的异十钨酸铜b化合物的合成、结构及抗癌活性

本研究将铜离子和甘氨酸结合到反十钨酸盐阴离子[H4W12O42]8 -中，通过自组装方法合成了一种基于多金属氧酸盐的无机-有机杂化材料Na4[Cu4(Gly)2(HGly)2(H4W12O42)]Cl2·20H2O (1) （Gly =甘氨酸）。采用单晶x射线衍射、元素分析、粉末x射线衍射、FTIR、拉曼光谱、循环伏安（CV）和紫外可见光谱对化合物1的结构和性质进行了系统表征。此外，采用MTT法测定其对人肝癌细胞（HepG2）和人肾上皮细胞（HEK293T）的体外抗癌活性，IC50值为36.232±0.41 μM。研究结果表明，化合物1有效抑制肝癌细胞的增殖，突出了其作为基于多钨酸氧盐（POT）的抗癌药物开发的候选药物的潜力。

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来源期刊

Inorganic Chemistry 化学-无机化学与核化学

CiteScore

7.60

自引率

13.00%

发文量

1960

审稿时长

1.9 months

期刊介绍： Inorganic Chemistry publishes fundamental studies in all phases of inorganic chemistry. Coverage includes experimental and theoretical reports on quantitative studies of structure and thermodynamics, kinetics, mechanisms of inorganic reactions, bioinorganic chemistry, and relevant aspects of organometallic chemistry, solid-state phenomena, and chemical bonding theory. Emphasis is placed on the synthesis, structure, thermodynamics, reactivity, spectroscopy, and bonding properties of significant new and known compounds.