Thalamus as a neural marker of cognitive reserve in bilinguals with frontotemporal dementia

IF 2.5 1区文学 Q1 LINGUISTICS

Bilingualism: Language and Cognition Pub Date : 2025-04-22 DOI:10.1017/s136672892500015x

Nithin Thanissery, Faheem Arshad, Sunil Kumar Khokhar, Raghavendra Kenchaiah, Vikram Singh, Subasree Ramakrishnan, Jitender Saini, Narayanan Srinivasan, Bapi Raju Surampudi, Suvarna Alladi

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Abstract

Bilingualism delays the onset of dementia symptoms and contributes to cognitive reserve. However, the neural basis of this mechanism remains elusive. The few studies that have investigated neural mechanisms of cognitive reserve and bilingualism have focused on Alzheimer’s disease. This study investigated the neural basis of cognitive reserve among persons with frontotemporal dementia (FTD) using regional brain volumes. Sixty-eight persons with FTD (42 bilinguals and 26 monolinguals) were included. After propensity score matching for age, sex, education, FTD subtype and clinical severity, there were 26 bilinguals and 26 monolinguals. The results showed that bilinguals had reduced thalamic volume compared to monolinguals despite having similar cognitive performance. The results indicate that bilinguals were able to tolerate more severe atrophy compared to monolinguals while maintaining comparable cognitive abilities. Our study therefore suggests that bilingualism contributes to cognitive reserve in persons with FTD.

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丘脑作为额颞叶痴呆双语者认知储备的神经标志物

双语可以延缓痴呆症状的发作，并有助于认知储备。然而，这种机制的神经基础仍然难以捉摸。少数研究认知储备和双语的神经机制的研究主要集中在阿尔茨海默病上。本研究利用区域脑容量研究额颞叶痴呆患者认知储备的神经基础。包括68名FTD患者（42名双语者和26名单语者）。对年龄、性别、受教育程度、FTD亚型和临床严重程度进行倾向评分匹配后，共有26名双语者和26名单语者。结果表明，尽管认知能力相似，但双语者的丘脑体积比单语者要小。结果表明，与单语者相比，双语者能够忍受更严重的萎缩，同时保持相当的认知能力。因此，我们的研究表明，双语有助于FTD患者的认知储备。

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来源期刊

Bilingualism: Language and Cognition Multiple-

CiteScore

8.90

自引率

16.70%

发文量