Metathesis Depolymerization of a Fluorogenic Self-Immolative Polymer

IF 5.1 Q1 POLYMER SCIENCE

ACS Macro Letters Pub Date : 2025-04-21 DOI:10.1021/acsmacrolett.5c00192

Gavin J. Giardino, Jia Niu

引用次数: 0

Abstract

We report a self-immolative polymer (SIP) that generates a fluorescent response upon metathesis depolymerization. Functionally distinct from other degradable polymers, SIPs offer the ability to release many subunits per one signal molecule, making them advantageous for a variety of applications such as molecular detection and signal amplification. Utilizing robust copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) chemistry to orthogonally functionalize alkynes, fluorophore coumarin and quencher 4-((4-(dimethylamino)phenyl)azo) (DABCYL) were efficiently installed as side chains on the SIP. The depolymerization mediated by Grubbs 3rd-generation (G3) organoruthenium initiator enabled a fluorescence turn-on response under nanomolar SIP concentrations. To demonstrate the utility of the fluorogenic SIP, we showed a temperature-dependent fluorescence turn-on of this metathesis-triggered SIP using a thermally responsive Grubbs 2nd-generation (G2) organoruthenium initiator.

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一种荧光自焚聚合物的复分解解聚

我们报告了一种自焚聚合物（SIP），在复分解解聚时产生荧光响应。从功能上不同于其他可降解聚合物，SIPs提供了每一个信号分子释放许多亚基的能力，使它们在分子检测和信号放大等各种应用中具有优势。利用铜(I)催化叠氮化物-炔环加成（CuAAC）化学对炔进行正交官能化，荧光基团香豆素和猝灭剂4-（（4-（二甲氨基）苯基）偶氮）（DABCYL）作为侧链有效地安装在SIP上。由Grubbs第三代（G3）有机钌引发剂介导的解聚在纳米摩尔SIP浓度下实现了荧光开启响应。为了证明荧光SIP的实用性，我们使用热响应的Grubbs第二代（G2）有机钌引发剂展示了这种合成触发SIP的温度依赖荧光开启。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Macro Letters 化学-

CiteScore

10.40

自引率

3.40%

发文量

209

审稿时长

1 months

期刊介绍： ACS Macro Letters publishes research in all areas of contemporary soft matter science in which macromolecules play a key role, including nanotechnology, self-assembly, supramolecular chemistry, biomaterials, energy generation and storage, and renewable/sustainable materials. Submissions to ACS Macro Letters should justify clearly the rapid disclosure of the key elements of the study. The scope of the journal includes high-impact research of broad interest in all areas of polymer science and engineering, including cross-disciplinary research that interfaces with polymer science. With the launch of ACS Macro Letters, all Communications that were formerly published in Macromolecules and Biomacromolecules will be published as Letters in ACS Macro Letters.