Retinal Oxygen Kinetics and Hemodynamics in Choroidal Melanoma After Iodine-125 Plaque Radiotherapy Using a Novel Structural-Functional Imaging Analysis System

IF 3.1 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2025-04-22 DOI:10.1002/cam4.70854

Haihan Zhang, Jingyuan Zhu, Yueming Liu, Shiyi Yin, Jinyuan Wang, Yao Yao, Haowen Li, Ximeng Feng, Chuanqing Zhou, Qiushi Ren, Wenbin Wei

{"title":"Retinal Oxygen Kinetics and Hemodynamics in Choroidal Melanoma After Iodine-125 Plaque Radiotherapy Using a Novel Structural-Functional Imaging Analysis System","authors":"Haihan Zhang, Jingyuan Zhu, Yueming Liu, Shiyi Yin, Jinyuan Wang, Yao Yao, Haowen Li, Ximeng Feng, Chuanqing Zhou, Qiushi Ren, Wenbin Wei","doi":"10.1002/cam4.70854","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>To investigate the changes in retinal oxygen kinetics and hemodynamics in patients with choroidal melanoma (CM) within 2 years before and after iodine-125 plaque radiotherapy (PRT) using a novel noninvasive structure-functional imaging analysis system.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A novel noninvasive cost-effective imaging analysis system that integrates multimodal structural and functional retinal imaging techniques has been used, which allows rapid acquisition of vascular structural, hemodynamic, and oxygenation metrics using multispectral imaging (MSI) and laser speckle contrast imaging (LSCI) techniques. Follow-ups have been arranged at the time before plaque implantation surgery, and 1 month, 3 months, 6 months, 12 months, 18 months, and 24 months after iodine-125 plaque removal.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>CM patients after PRT demonstrated a significant decrease in retinal arterial oxygen concentration (CO<sub>2</sub><sup>a</sup>), arterial oxygen saturation (SO<sub>2</sub><sup>a</sup>), oxygen utilization (SO<sub>2</sub><sup>av</sup>, CO<sub>2</sub><sup>av</sup>), and metabolism (oxygen extraction fraction, OEF) over time. However, there was no significant difference in SO<sub>2</sub> and CO<sub>2</sub> compared with healthy controls. Systolic time (Time_sr), acceleration time index (ATI), and resistivity index (RI) gradually increase over time; ATI and RI were significantly higher than those of the healthy controls. At baseline, mean arterial blood flow velocity (BFVa) and mean arterial retinal blood flow (RBFa) in CM eyes were significantly higher than those in the healthy control group. BFVa and RBFa showed a decreasing trend over time after PRT. In addition, some retinal oxygen kinetics and hemodynamic indicators were also correlated with tumor size, patient gender, and age.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>CM patients after iodine-125 plaque radiotherapy had significant retinal and vascular changes. Future research should focus on rapidly screening radiation microvascular complications and exploring more timely and effective interventions to protect visual function in CM patients.</p>\n </section>\n </div>","PeriodicalId":139,"journal":{"name":"Cancer Medicine","volume":"14 8","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.70854","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Medicine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cam4.70854","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

To investigate the changes in retinal oxygen kinetics and hemodynamics in patients with choroidal melanoma (CM) within 2 years before and after iodine-125 plaque radiotherapy (PRT) using a novel noninvasive structure-functional imaging analysis system.

Methods

A novel noninvasive cost-effective imaging analysis system that integrates multimodal structural and functional retinal imaging techniques has been used, which allows rapid acquisition of vascular structural, hemodynamic, and oxygenation metrics using multispectral imaging (MSI) and laser speckle contrast imaging (LSCI) techniques. Follow-ups have been arranged at the time before plaque implantation surgery, and 1 month, 3 months, 6 months, 12 months, 18 months, and 24 months after iodine-125 plaque removal.

Results

CM patients after PRT demonstrated a significant decrease in retinal arterial oxygen concentration (CO₂^a), arterial oxygen saturation (SO₂^a), oxygen utilization (SO₂^av, CO₂^av), and metabolism (oxygen extraction fraction, OEF) over time. However, there was no significant difference in SO₂ and CO₂ compared with healthy controls. Systolic time (Time_sr), acceleration time index (ATI), and resistivity index (RI) gradually increase over time; ATI and RI were significantly higher than those of the healthy controls. At baseline, mean arterial blood flow velocity (BFVa) and mean arterial retinal blood flow (RBFa) in CM eyes were significantly higher than those in the healthy control group. BFVa and RBFa showed a decreasing trend over time after PRT. In addition, some retinal oxygen kinetics and hemodynamic indicators were also correlated with tumor size, patient gender, and age.

Conclusion

CM patients after iodine-125 plaque radiotherapy had significant retinal and vascular changes. Future research should focus on rapidly screening radiation microvascular complications and exploring more timely and effective interventions to protect visual function in CM patients.

Abstract Image

查看原文本刊更多论文

使用新型结构-功能成像分析系统研究碘-125斑块放疗后脉络膜黑色素瘤视网膜氧动力学和血流动力学

应用一种新型的无创结构-功能成像分析系统研究碘-125斑块放疗（PRT）前后2年内脉络膜黑色素瘤（CM）患者视网膜氧动力学和血流动力学的变化。方法采用一种新型的无创低成本成像分析系统，该系统集成了多模态结构和功能视网膜成像技术，可以使用多光谱成像（MSI）和激光散斑对比成像（LSCI）技术快速获取血管结构、血流动力学和氧合指标。随访时间分别为菌斑植入手术前、去除碘-125菌斑后1个月、3个月、6个月、12个月、18个月、24个月。结果PRT后CM患者视网膜动脉血氧浓度（CO2a）、动脉血氧饱和度（SO2a）、氧利用率（SO2av、CO2av）和代谢（氧提取分数，OEF）随时间显著降低。然而，与健康对照组相比，SO2和CO2无显著差异。收缩时间（Time_sr）、加速时间指数（ATI）、电阻率指数（RI）随时间逐渐增大；ATI和RI明显高于健康对照组。在基线时，CM眼平均动脉血流速度（BFVa）和平均动脉视网膜血流（RBFa）显著高于健康对照组。在PRT后，BFVa和RBFa随时间的推移呈下降趋势。此外，一些视网膜氧动力学和血流动力学指标也与肿瘤大小、患者性别和年龄相关。结论CM患者经碘-125斑块放疗后视网膜及血管有明显改变。未来的研究应侧重于快速筛查放射微血管并发症，探索更及时有效的干预措施来保护CM患者的视觉功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.