Induction of zebrafish embryotoxicity by zinc oxide nanoparticles: a meta-analysis

IF 2.1 4区材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Nanoparticle Research Pub Date : 2025-04-22 DOI:10.1007/s11051-025-06315-0

Xiaomin Wei, Guiqiang Xu, Zengjin Wang

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Abstract

Numerous studies have shown zinc oxide nanoparticles (ZnO NPs) inducing zebrafish embryotoxicity. However, due to the complexity and heterogeneity of published data, the relationship between exposure dose and their toxicity is confounded. In this study, we present a rigorous approach for extracting and analyzing pertinent knowledge from the originally published evidence on embryotoxicity of ZnO NPs. The available 17 studies were determined by random effects model of meta-analysis. After exposure dose subgroup analysis from 0.5 to 50 mg/L, we found that ZnO NPs decreased the hatching rate of zebrafish embryo at lower dose of 0.5 mg/L (standardized mean difference (SMD) = − 2.20, 95% CI = [− 3.71, − 0.68]). Moreover, we summarized the potential mechanisms of ZnO NP-induced embryotoxicity and found that particle form or released Zn ions form nanoparticles entered into embryo and induced oxidative stress, inflammation and apoptosis. Our results help people get to know more about nano-embryotoxicity and provide a criterion for future studies to develop nanoparticles that are safe by design.

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氧化锌纳米颗粒诱导斑马鱼胚胎毒性：一项荟萃分析

大量研究表明氧化锌纳米颗粒（ZnO NPs）可诱导斑马鱼胚胎毒性。然而，由于已发表数据的复杂性和异质性，暴露剂量与其毒性之间的关系是混淆的。在这项研究中，我们提出了一种严格的方法，从最初发表的关于ZnO NPs胚胎毒性的证据中提取和分析相关知识。采用meta分析的随机效应模型确定17项研究。在0.5 ~ 50 mg/L剂量亚组分析中发现，0.5 mg/L剂量下，ZnO NPs降低了斑马鱼胚胎的孵化率（标准化平均差(SMD) =−2.20,95% CI =[−3.71,−0.68]）。此外，我们总结了ZnO np诱导胚胎毒性的潜在机制，发现颗粒形式或以纳米颗粒形式释放的Zn离子进入胚胎并诱导氧化应激、炎症和细胞凋亡。我们的研究结果有助于人们更多地了解纳米胚胎毒性，并为未来研究开发设计安全的纳米颗粒提供标准。

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来源期刊

Journal of Nanoparticle Research 工程技术-材料科学：综合

CiteScore

4.40

自引率

4.00%

发文量

198

审稿时长

3.9 months

期刊介绍： The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.