Higher prognostic nutritional index is associated with lower incidence of sarcopenia

Abstract

Sarcopenia is a syndrome of progressive, generalized decline in skeletal muscle function and muscle mass. As one of the key factors affecting sarcopenia, nutritional status plays an important role in the occurrence and development of sarcopenia. Therefore, this study selected the National Health and Nutrition Examination Survey (NHANES) database to study the effect of prognostic nutritional index (PNI) on sarcopenia. A total of 8058 adults were included in this study. In multiple linear regression analysis, PNI levels were significantly negatively associated with sarcopenia [0.89 (0.85,0.93)]; The risk of sarcopenia was reduced by 52% in the highest quartile of PNI compared with the lowest quartile [0.48 (0.31,0.74)]; This negative association was sustained in stratified subgroups. According to the generalized additive model and the results of smooth curve fitting, PNI was negatively associated with sarcopenia. Higher PNI was associated with a lower incidence of sarcopenia.