Association between multiple sclerosis lesion location, migraine and tension-type headache: A cross-sectional study

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Clinical Neuroscience Pub Date : 2025-04-21 DOI:10.1016/j.jocn.2025.111250

Panagiotis Gklinos , Maria-Eleftheria Evangelopoulos , Georgios Velonakis , Dimos-Dimitrios Mitsikostas

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引用次数: 0

Abstract

Background

An increased prevalence of migraine in people with MS (pwMS) has been documented over the past decade, with one of the leading explanations being the presence of lesions within regions, critical for pain modulation.

Objective

To investigate whether lesions within pain areas are associated with primary headaches in pwMS.

Methods

PwMS fulfilling the 2017 Mc Donald criteria were recruited prospectively in the study. Patients underwent a detailed neurological examination and assesment for primary headache disorders. Brain MRI scans were obtained and assessed. Odd-ratios (ORs) were calculated to examine the potential association of lesions within pain-perceiving brain regions and primary headache disorders.

Results

A total of 96 participants were included in the study. After adjusting for potential confounding factors, PAG lesions were statistically significantly associated with migraine (OR = 4.7; 95 % CI: 1.5 to 14.59; p = 0.008). Similarly, thalamic and cortical lesions were also statistically significantly associated with an increased prevalence of migraine (OR = 7.2; 95 %CI: 1.37 to 37.79; p = 0.02 and OR = 9.1; 95 %CI: 1.53 to 54.72; p = 0.02 respectively)

Conclusions

Lesions within critical brain regions are associated with migraine and are possibly the leading cause of the increased prevalence of migraine in pwMS.

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多发性硬化症病变部位、偏头痛和紧张性头痛之间的关系：一项横断面研究

背景：在过去的十年中，多发性硬化症（pwMS）患者偏头痛的患病率有所增加，其中一个主要的解释是在疼痛调节的关键区域内存在病变。目的探讨疼痛区病变是否与原发性头痛有关。方法前瞻性招募符合2017年Mc - Donald标准的spwms。患者接受了详细的神经学检查和原发性头痛疾病的评估。获得脑MRI扫描并进行评估。计算奇比（or）来检查疼痛感知脑区域内病变与原发性头痛疾病的潜在关联。结果本研究共纳入96名受试者。在调整了潜在的混杂因素后，PAG病变与偏头痛有统计学意义上的显著相关性(OR = 4.7；95% CI: 1.5 ~ 14.59；p = 0.008)。同样，丘脑和皮质病变也与偏头痛患病率增加有统计学意义上的显著相关(OR = 7.2；95% CI: 1.37 ~ 37.79；p = 0.02, OR = 9.1；95% CI: 1.53 ~ 54.72；结论关键脑区病变与偏头痛有关，可能是pwMS患者偏头痛患病率增加的主要原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Neuroscience 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

402

审稿时长

40 days

期刊介绍： This International journal, Journal of Clinical Neuroscience, publishes articles on clinical neurosurgery and neurology and the related neurosciences such as neuro-pathology, neuro-radiology, neuro-ophthalmology and neuro-physiology. The journal has a broad International perspective, and emphasises the advances occurring in Asia, the Pacific Rim region, Europe and North America. The Journal acts as a focus for publication of major clinical and laboratory research, as well as publishing solicited manuscripts on specific subjects from experts, case reports and other information of interest to clinicians working in the clinical neurosciences.