HPV vaccines – A game changer for preventing HPV-related cancers

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2025-04-10 DOI:10.1016/j.ijmmb.2025.100847

John Dickson Calvin Devadasan , Karthick Nithyanandhan , Gnanadurai John Fletcher, Rajesh Kannangai, Priya Abraham

引用次数: 0

Abstract

Introduction

Human papillomaviruses (HPV) cause almost all cervical cancer cases globally, with the high-risk genotypes 16/18 causing at least 70 % of cancers, of which most cases occur in low-to-middle-income countries. Prophylactic vaccination plays a major role in the prevention of cervical cancer, which could effectively prevent the incidence of HPV infection. The L1 protein, which, when assembled into virus-like particles, induces HPV-type-specific neutralizing antibodies, which form the basis of all currently licensed HPV vaccines. There are six approved prophylactic HPV vaccines. All these vaccines are designed to prevent HPV 16 and 18-associated cervical precancers, thereby preventing approximately 70 % of the cancers. This review looks at the current HPV prophylactic vaccines, their mechanism of action, vaccination schedules, and the cost of different vaccines.

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HPV疫苗——预防HPV相关癌症的游戏规则改变者

全球几乎所有宫颈癌病例都是由人乳头瘤病毒（HPV）引起的，其中高风险基因型16/18导致至少70%的癌症，其中大多数病例发生在低收入和中等收入国家。预防性接种疫苗在预防宫颈癌中起着重要作用，可有效预防HPV感染的发生。L1蛋白，当组装成病毒样颗粒时，诱导HPV型特异性中和抗体，这是目前所有许可的HPV疫苗的基础。目前有六种经批准的预防性HPV疫苗。所有这些疫苗都是为了预防HPV 16和18相关的宫颈癌前病变，从而预防大约70%的癌症。这篇综述着眼于目前的HPV预防性疫苗，它们的作用机制，疫苗接种时间表和不同疫苗的成本。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.