Understanding EBV infection and EBV-associated lymphomas in children

IF 2.8 3区医学 Q3 VIROLOGY

Virology Pub Date : 2025-04-16 DOI:10.1016/j.virol.2025.110544

Chabay P

引用次数: 0

Abstract

The Epstein-Barr virus (EBV) infects over 90 % of the human population, often behaving as a harmless passenger in most hosts. However, since 1997, it has been classified as a group 1 carcinogen by the International Agency for Research on Cancer (IARC) due to its causal association with several malignancies. Most studies on EBV primary infection and EBV-associated lymphomas have been performed in adults from developed countries. The complex interplay between age of acquisition and symptomatic versus asymptomatic infection is related to the subsequent risk of EBV-associated cancers or autoimmune diseases. This review discusses some characteristics of EBV infection and EBV-associated lymphomas in children from low- and middle-income regions, with a focus on the local immune response.

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了解儿童eb病毒感染和eb病毒相关淋巴瘤

爱泼斯坦-巴尔病毒（EBV）感染了超过90%的人口，在大多数宿主中通常表现为无害的乘客。然而，自1997年以来，由于其与几种恶性肿瘤的因果关系，它已被国际癌症研究机构（IARC）列为1类致癌物。大多数关于EBV原发感染和EBV相关淋巴瘤的研究都是在发达国家的成年人中进行的。感染年龄与有症状或无症状感染之间的复杂相互作用与ebv相关癌症或自身免疫性疾病的后续风险有关。本文综述了中低收入地区儿童eb病毒感染和eb病毒相关淋巴瘤的一些特征，重点讨论了局部免疫反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virology 医学-病毒学

CiteScore

6.00

自引率

0.00%

发文量

157

审稿时长

50 days

期刊介绍： Launched in 1955, Virology is a broad and inclusive journal that welcomes submissions on all aspects of virology including plant, animal, microbial and human viruses. The journal publishes basic research as well as pre-clinical and clinical studies of vaccines, anti-viral drugs and their development, anti-viral therapies, and computational studies of virus infections. Any submission that is of broad interest to the community of virologists/vaccinologists and reporting scientifically accurate and valuable research will be considered for publication, including negative findings and multidisciplinary work.Virology is open to reviews, research manuscripts, short communication, registered reports as well as follow-up manuscripts.