Alterations in structural and functional magnetic resonance imaging associated with cognitive function in patients with treatment-naïve first-episode major depressive disorder

IF 5.3 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry Pub Date : 2025-04-15 DOI:10.1016/j.pnpbp.2025.111367

Chenyu Liu , Hehua Li , Shixuan Feng , Ziyun Zhang , Miaolan Huang , Shisong Lin , Liangda Zhong , Dongchang Huang , Yuanyuan Huang , Kai Wu , Fengchun Wu

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引用次数: 0

Abstract

Background

Cognitive impairment is a prominent feature in the clinical presentation of major depressive disorder (MDD). Patients with MDD have brain structural and functional abnormalities. However, the association between such abnormalities and cognitive function remains unclear.

Methods

For this research, 105 patients with treatment-naïve first-episode MDD and 53 healthy controls (HCs) underwent magnetic resonance imaging (MRI) and neuropsychological assessment. The MRI main indicators included sulcus depth (SD), local gyration index (LGI) and amplitude of low frequency fluctuations (ALFF). The MATRICS Consensus Cognitive Battery (MCCB) was used for neuropsychological assessment. The support vector machine (SVM) was used to assess the accuracy of the classification.

Results

Compared with the HCs, the patients with MDD had significant decreases in five dimensions of the MCCB, as well as in SD in the left superior temporal sulcus and inferior parietal cortex, but had an increases in LGI in the left precuneus cortex and pericalcarine cortex and ALFF of the left calcarine fissure and surrounding cortex. In addition, the visual learning score (one MCCB dimension) was negatively associated with the SD of the left superior temporal sulcus and positively associated with the ALFF of left calcarine fissure and surrounding cortex. The SVM has a relatively good ability to distinguish patients with MDD and HCs.

Conclusion

Cognitive impairment in patients with MDD was associated with abnormal an SD and ALFF. These findings help to further understand cognitive impairment in patients with MDD.

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treatment-naïve首发重度抑郁症患者结构和功能磁共振成像改变与认知功能相关

背景认知障碍是重度抑郁症（MDD）临床表现的一个突出特征。重度抑郁症患者有大脑结构和功能异常。然而，这种异常与认知功能之间的关系尚不清楚。方法在本研究中，105例treatment-naïve首发MDD患者和53例健康对照（hc）接受了磁共振成像（MRI）和神经心理学评估。MRI主要指标包括沟深（SD）、局部旋转指数（LGI）和低频波动幅度（ALFF）。使用matrix共识认知电池（MCCB）进行神经心理评估。使用支持向量机（SVM）来评估分类的准确性。结果与正常人相比，重度抑郁症患者MCCB的5个维度以及左侧颞上沟和顶叶下皮层的SD均显著降低，而左侧楔前叶皮层和骨膜外皮层的LGI以及左侧骨膜裂和周围皮层的ALFF均明显升高。此外，视觉学习评分（MCCB的一个维度）与左侧颞上沟的SD呈负相关，与左侧钙状裂及周围皮层的ALFF呈正相关。SVM对MDD和hc患者有较好的区分能力。结论重度抑郁症患者认知功能障碍与SD、ALFF异常有关。这些发现有助于进一步了解重度抑郁症患者的认知障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Neuro-Psychopharmacology & Biological Psychiatry 医学-精神病学

CiteScore

12.00

自引率

1.80%

发文量

153

审稿时长

56 days

期刊介绍： Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.