The role of Tim-3+T cell subsets in the peripheral blood of patients with COVID-19 and diabetes

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-04-03 DOI:10.1016/j.isci.2025.112339

Wenjun Luo , Mingjiu Zhao , Mengyao Gu , Jiaqi Huang , Shiyao Wu , Bin Zhao

引用次数: 0

Abstract

Corona Virus Disease 2019 (COVID-19) and diabetes interact to influence disease severity, yet their combined immunological characteristics remain unclear. Here, we analyzed Tim-3+ T cells in patients with COVID-19, Type 1 Diabetes (T1D), or both conditions. COVID-19 reduced peripheral T cell subsets but increased Tim-3+ cells, while T1D and COVID-19 with T1D showed the opposite pattern. Patients with Type 2 Diabetes (T2D) exhibited no significant alterations. In human samples and mouse models, Tim-3+ T cells demonstrated impaired activation and cytokine production. RNA-seq analysis in mice and RT-PCR analysis in human samples together identified the dysregulation of the JAK-STAT pathway in Tim-3+ T cells. These findings highlight Tim-3-mediated JAK-STAT dysregulation in T-cells as a potential mechanism linking COVID-19 and T1D, offering insights for therapeutic targeting.

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Tim-3+T细胞亚群在COVID-19和糖尿病患者外周血中的作用

2019冠状病毒病（COVID-19）和糖尿病相互作用影响疾病严重程度，但它们的综合免疫学特征仍不清楚。在这里，我们分析了COVID-19、1型糖尿病（T1D）或两种情况患者的Tim-3+ T细胞。COVID-19降低了外周T细胞亚群，但增加了Tim-3+细胞，而T1D和COVID-19合并T1D呈现相反的模式。2型糖尿病（T2D）患者没有明显的改变。在人类样本和小鼠模型中，Tim-3+ T细胞表现出激活和细胞因子产生受损。小鼠的RNA-seq分析和人样本的RT-PCR分析共同鉴定了Tim-3+ T细胞中JAK-STAT通路的失调。这些发现强调了t细胞中tim -3介导的JAK-STAT失调是连接COVID-19和T1D的潜在机制，为治疗靶向提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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