{"title":"Continuous-Flow Microreactor System for Enhanced Selectivity and Safety in Nitrobenzene Nitration","authors":"Wenyuan Zhao, Simeng Wang, Wenxian Zhao, Wei wei and Dongmao Yan*, ","doi":"10.1021/acsomega.5c0037710.1021/acsomega.5c00377","DOIUrl":null,"url":null,"abstract":"<p >Dinitrobenzene, a crucial intermediate in pesticide and dye production, is typically synthesized through the exothermic nitration of nitrobenzene. This study presents a continuous-flow microreactor system integrated with micromixers to enhance selectivity and safety in the nitration process. An open-source Python program was developed to precisely control the mass flow rate ratio of nitrobenzene to the mixed acid. By optimizing reaction conditions and employing sodium dodecyl sulfate (SDS) as a surfactant, the selectivity of p-dinitrobenzene was minimized to 0.44%, while hazardous nitrophenol byproducts were reduced to 112 ppm─a significant improvement compared to the 509 ppm observed in traditional batch processes. Compared to traditional batch reactors, the microreactor system significantly lowered p-dinitrobenzene selectivity and minimized nitrophenol and trinitrobenzene formation, highlighting its suitability for industrial-scale applications.</p>","PeriodicalId":22,"journal":{"name":"ACS Omega","volume":"10 15","pages":"15503–15510 15503–15510"},"PeriodicalIF":3.7000,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsomega.5c00377","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Omega","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsomega.5c00377","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Dinitrobenzene, a crucial intermediate in pesticide and dye production, is typically synthesized through the exothermic nitration of nitrobenzene. This study presents a continuous-flow microreactor system integrated with micromixers to enhance selectivity and safety in the nitration process. An open-source Python program was developed to precisely control the mass flow rate ratio of nitrobenzene to the mixed acid. By optimizing reaction conditions and employing sodium dodecyl sulfate (SDS) as a surfactant, the selectivity of p-dinitrobenzene was minimized to 0.44%, while hazardous nitrophenol byproducts were reduced to 112 ppm─a significant improvement compared to the 509 ppm observed in traditional batch processes. Compared to traditional batch reactors, the microreactor system significantly lowered p-dinitrobenzene selectivity and minimized nitrophenol and trinitrobenzene formation, highlighting its suitability for industrial-scale applications.
ACS OmegaChemical Engineering-General Chemical Engineering
CiteScore
6.60
自引率
4.90%
发文量
3945
审稿时长
2.4 months
期刊介绍：
ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.
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