Rapid UHPLC-MS/MS Detection of Prohibited Drugs in Cosmetics Using Pass-Through SPE

IF 3.7 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2025-04-10 DOI:10.1021/acsomega.5c0131910.1021/acsomega.5c01319

Jie Mao, Jing Peng, Yingjie Zhu, Xin Jiang, Yanqing Cao, Tianyue Zhao, Suhe Dong, Fangting Dong, Kun He* and Na Wang*,

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引用次数: 0

Abstract

Prolonged exposure to drugs prohibited in cosmetics may cause irritation and allergic reactions in humans. In this study, a method using ultrahigh performance liquid chromatography-tandem mass spectrometry was established for the simultaneous determination of 64 prohibited drugs spanning 11 categories, including 39 antibiotics, 8 antiallergics, 7 anesthetics, and 10 hormones. Typical cosmetic samples containing toner, cream, and oil matrices were extracted using a 70% acetonitrile solvent system with 1% formic acid and purified using a pass-through cleanup solid-phase extraction approach with a PRiME hydrophobic–lipophilic balanced column. Analytes covering a wide range of polarities showed excellent recoveries between 70 and 120%, with relative standard deviations of <11%. Excellent sensitivities ranging from 0.1 to 1 μg/kg were achieved with the limits of quantification. This method provides a rapid and comprehensive targeted strategy for the analysis of multiclass prohibited drugs in various cosmetic matrices. Finally, analysis of 20 cosmetic products using the optimized method identified prohibited substances in 6 samples at concentrations spanning 7 orders of magnitude.

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超高效液相色谱-质谱联用快速检测化妆品中违禁药品

长期接触化妆品中的禁用药物可能会对人体产生刺激和过敏反应。本研究采用超高效液相色谱-串联质谱法同时测定了 11 类 64 种禁用药物，包括 39 种抗生素、8 种抗过敏剂、7 种麻醉剂和 10 种激素。典型的化妆品样品含有爽肤水、膏霜和油脂基质，使用含 1%甲酸的 70% 乙腈溶剂系统进行提取，并使用 PRiME 疏水亲油平衡柱通过净化固相萃取方法进行纯化。分析物的极性范围很广，回收率在 70% 至 120% 之间，相对标准偏差为 11%。灵敏度在 0.1 至 1 μg/kg 之间，定量限为 0.1 μg/kg。该方法为分析各种化妆品基质中的多类违禁药物提供了一种快速、全面的靶向策略。最后，使用优化方法对 20 种化妆品进行了分析，在 6 种样品中发现了禁用物质，其浓度跨越了 7 个数量级。

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.