Radiofrequency Dynamic Therapy on Cancer of Gallium–Indium Liquid Metal Nanoemulsion Stabilized by Gold Nanoclusters

IF 18.5 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Functional Materials Pub Date : 2025-04-21 DOI:10.1002/adfm.202425330

Shidong Zou, Qingqing Zhang, Mengqin Guo, Shuai Yao, Shaokun Dong, Can Hong, Dingwen Shi, Le Zhao, Qing Du, Xiangliang Yang, Yanbing Zhao

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Abstract

Dynamic therapy (DT) is a promising method for enhancing tumor killing efficacy. In this study, radiofrequency dynamic therapy (RFDT) is proposed as a mode of DT with high tissue penetration for deep-seated cancers. Gold nanocluster-stabilizing liquid metal nanodroplets (GaNAs) with well-defined structures are developed as RF-responsive nanoantennas for RFDT. Substantial production of reactive oxygen species (ROS) is achieved through RF-induced polarization in GaNA, which effectively enhances the redox reaction between gallium and oxygen. The in vitro cytotoxicity assay suggests that the IC₅₀ of GaNA decreases ca. 14 folds as RF irradiation is switched on. Furthermore, GaNA-mediated RFDT enhances the immunogenic cell death of cancer cells and ameliorates the hypoxic tumor microenvironment via catalase-like activity, RF-activated ROS/heat generation, suppressing tumor growth and metastasis. In summary, GaNA-mediated RFDT provides a DT mode for treating deep tumors, owing to the excellent tissue penetration of RF electromagnetic waves.

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金纳米团簇稳定镓铟液态金属纳米乳肿瘤的射频动态治疗

动态治疗是一种很有前途的提高肿瘤杀伤效果的方法。在本研究中，射频动态治疗（RFDT）被认为是一种具有高组织穿透性的深部肿瘤的DT模式。研究了结构明确的金纳米团簇稳定液态金属纳米液滴（GaNAs）作为RFDT射频响应纳米天线。活性氧（ROS）的大量产生是通过射频诱导的GaNA极化实现的，这有效地增强了镓和氧之间的氧化还原反应。体外细胞毒性实验表明，射频照射后，GaNA的IC50降低约14倍。此外，gana介导的RFDT通过过氧化氢酶样活性、rf激活的ROS/热生成、抑制肿瘤生长和转移，增强了癌细胞的免疫原性细胞死亡，改善了缺氧的肿瘤微环境。综上所述，由于射频电磁波具有良好的组织穿透性，gana介导的RFDT为治疗深部肿瘤提供了一种DT模式。

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来源期刊

Advanced Functional Materials 工程技术-材料科学：综合

CiteScore

29.50

自引率

4.20%

发文量

2086

审稿时长

2.1 months

期刊介绍： Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week. Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.