A cognitive map for value-guided choice in the ventromedial prefrontal cortex

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2025-04-21 DOI:10.1016/j.cell.2025.03.038

Sebastijan Veselic, Timothy H. Muller, Elena Gutierrez, Timothy E.J. Behrens, Laurence T. Hunt, James L. Butler, Steven W. Kennerley

引用次数: 0

Abstract

The prefrontal cortex (PFC) is crucial for economic decision-making. However, how PFC value representations facilitate flexible decisions remains unknown. We reframe economic decision-making as a navigation process through a cognitive map of choice values. We found rhesus macaques represented choices as navigation trajectories in a value space using a grid-like code. This occurred in ventromedial PFC (vmPFC) local field potential theta frequency across two datasets. vmPFC neurons deployed the same grid-like code and encoded chosen value. However, both signals depended on theta phase: occurring on theta troughs but on separate theta cycles. Finally, we found sharp-wave ripples—a key signature of planning and flexible behavior—in vmPFC. Thus, vmPFC utilizes cognitive map-based computations to organize and compare values, suggesting an alternative architecture for economic choice in PFC.

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腹内侧前额叶皮层价值导向选择的认知图

前额叶皮层（PFC）对经济决策至关重要。然而，PFC值表示如何促进灵活决策仍然未知。我们将经济决策重新定义为通过选择价值的认知地图进行导航的过程。我们发现恒河猴使用网格状代码将选择表示为价值空间中的导航轨迹。这发生在两个数据集的腹内侧PFC （vmPFC）局部场电位θ频率。vmPFC神经元部署相同的网格状代码并编码选择值。然而，这两个信号都依赖于θ相位：发生在θ波谷上，但在不同的θ周期上。最后，我们在vmPFC中发现了锐波涟漪——规划和灵活行为的一个关键特征。因此，vmPFC利用基于认知地图的计算来组织和比较值，为PFC中的经济选择提供了另一种架构。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.