Estimated Incidence of Hospitalisations and Deaths Attributable to Respiratory Syncytial Virus Infections in Adults in Australia Between 2010 and 2019

IF 4.3 4区医学 Q1 INFECTIOUS DISEASES

Influenza and Other Respiratory Viruses Pub Date : 2025-04-20 DOI:10.1111/irv.70092

Zirke Wiid, Caihua Liang, Robin Bruyndonckx, Lauren Mason, Aleksandra Polkowska-Kramek, Pimnara Peerawaranun, Mikel Esnaola, Worku Biyadgie Ewnetu, Somsuvro Basu, David Witcombe, Bradford D. Gessner, Elizabeth Begier

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引用次数: 0

Abstract

Background

Respiratory syncytial virus (RSV) morbidity and mortality in adults are often underestimated due to nonspecific symptoms, limited standard-of-care testing and lower diagnostic testing sensitivity compared with children. To accurately evaluate the RSV disease burden among adults in Australia, we conducted a model-based study to estimate RSV-attributable cardiorespiratory hospitalisation incidence and mortality rate.

Methods

A quasi-Poisson regression model was used to estimate RSV-attributable cardiorespiratory, respiratory and cardiovascular events, using weekly hospitalisation and mortality data from 2010 to 2019, accounting for periodic and aperiodic time trends and viral activity and allowing for potential overdispersion. The time-series model compared the variability in confirmed RSV events alongside variability in all-cause cardiorespiratory events identified from ICD-10-AM codes to estimate the number of RSV-attributable events, including undiagnosed RSV-related events.

Results

RSV-attributable incidence of cardiorespiratory hospitalisations increased with age and was highest among adults ≥ 65 years (329.5–386.6 cases per 100,000 person-years), nine times higher than in adults 18–64 years. The estimated incidence of RSV-attributable respiratory hospitalisations in adults ≥65 years (219.7–247.8 cases per 100,000 person-years) was 35-fold higher than in adults 18–64 years. RSV-attributable deaths accounted for 4% to 6% of cardiorespiratory deaths in adults ≥ 65 years, with RSV-attributable mortality rates ranging from 65.6 to 77.6 deaths per 100,000 person-years and respiratory mortality rates ranging from 20.3 to 24.0 deaths per 100,000 person-years, both 70-fold higher than in adults 18–64 years.

Conclusions

This study identified substantial RSV-associated morbidity and mortality among Australian adults and is the first study to report RSV-attributable mortality rates for Australia that account for untested events.

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2010年至2019年澳大利亚成年人因呼吸道合胞病毒感染而住院和死亡的估计发生率

与儿童相比，呼吸道合胞病毒（RSV）在成人中的发病率和死亡率往往被低估，原因是其非特异性症状、有限的标准护理检测和较低的诊断检测敏感性。为了准确评估澳大利亚成年人的呼吸道合胞病毒疾病负担，我们进行了一项基于模型的研究，以估计呼吸道合胞病毒导致的心肺住院发病率和死亡率。方法采用准泊松回归模型，利用2010年至2019年的每周住院和死亡率数据，考虑周期性和非周期性时间趋势和病毒活性，并考虑潜在的过度分散，估计rsv导致的心肺、呼吸和心血管事件。该时间序列模型比较了确诊RSV事件的变异性和从ICD-10-AM代码中确定的全因心肺事件的变异性，以估计RSV归因事件的数量，包括未确诊的RSV相关事件。结果rsv归因的心血管住院发生率随年龄增长而增加，在≥65岁的成年人中最高（每10万人年329.5-386.6例），是18-64岁成年人的9倍。在≥65岁的成年人中，rsv引起的呼吸道住院的估计发生率（每10万人年219.7-247.8例）比18-64岁的成年人高35倍。在年龄≥65岁的成年人中，rsv导致的死亡占心肺疾病死亡的4%至6%，rsv导致的死亡率为每10万人年65.6至77.6例死亡，呼吸系统死亡率为每10万人年20.3至24.0例死亡，两者均比18-64岁的成年人高70倍。本研究确定了澳大利亚成年人中与rsv相关的大量发病率和死亡率，并且是第一个报告澳大利亚rsv可归因于未测试事件的死亡率的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.