Osteosarcopenia, osteoarthritis and frailty: a two-sample Mendelian randomization study

IF 3.4 3区医学 Q2 GERIATRICS & GERONTOLOGY

Aging Clinical and Experimental Research Pub Date : 2025-04-21 DOI:10.1007/s40520-025-03012-9

Jili Liu, Xin Xia, Zhaolin Wang, Yanqin Wang, Gang Qin

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引用次数: 0

Abstract

Background

Musculoskeletal disease, which has a complicated relationship with frailty, is a common clinical problem among elderly individuals.

Aims

This study evaluated the potential causal relationships between osteosarcopenia, osteoarthritis and frailty by Mendelian Randomization (MR) analysis.

Methods

This study employed a two-sample MR approach to investigate the causal relationships among osteosarcopenia, osteoarthritis and frailty. Published summary statistics were used to obtain instrumental variables at the genome-wide significance level.

Results

Among the age groups with osteoporosis, high total bone mineral density (TBMD) (45—60, OR = 0.966, 95% CI 0.940–0.993, P = 0.013) and TBMD (over 60, OR = 0.974, 95% CI 0.954–0.994, P = 0.011) reduced the risk of frailty. Similarly, high forearm BMD (FA-BMD), high ultradistal forearm BMD (UFA-BMD), and high Heel-BMD at different sites also reduced the risk of frailty (OR = 0.966, 95% CI 0.936–0.996, P = 0.028; OR = 0.975, 95% CI 0.953–0.997, P = 0.029; OR = 0.981, 95% CI 0.967–0.995, P = 0.008). Among the characteristics related to sarcopenia, grip strength in the left hand, grip strength in the right hand, appendicular lean mass, and walking pace were all protective factors for frailty (OR = 0.788, 95% CI 0.721–0.862, P < 0.001; OR = 0.800, 95% CI 0.737–0.869, P < 0.001; OR = 0.955, 95% CI 0.937–0.974, P = 0.000; OR = 0.480, 95% CI 0.388–0.593, P < 0.001), with low grip strength in those over 60 years of age significantly positively correlated with frailty (OR = 1.168, 95% CI 1.059–1.289, P = 0.002). The MR results of osteoarthritis and frailty revealed a causal relationship between specific joint sites and frailty, including KOA (OR = 1.086, 95% CI 1.017–1.160, P = 0.014), HOA (OR = 1.028, 95% CI 1.007–1.049, P = 0.009), and KOA/HOA (OR = 1.082, 95% CI 1.053–1.113, P = 0.000), increasing the risk of frailty.

Conclusion

Osteosarcopenia, osteoarthritis and frailty exhibit significant causal effects, rendering them risk factors for frailty. Therefore, in clinical practice, patients with osteosarcopenia and osteoarthritis should be required to undergo relevant interventions to reduce the risk of frailty.

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骨质疏松症、骨关节炎和虚弱：双样本孟德尔随机研究

背景肌肉骨骼疾病是老年人常见的临床问题，与虚弱有着复杂的关系。目的：本研究通过孟德尔随机化（MR）分析评估骨骼肌减少症、骨关节炎和虚弱之间的潜在因果关系。方法采用双样本MR方法探讨骨骼肌减少症、骨关节炎和虚弱之间的因果关系。使用已发表的汇总统计来获得全基因组显著性水平上的工具变量。结果骨质疏松患者中，高总骨密度（TBMD）（45 ~ 60, OR = 0.966, 95% CI 0.940 ~ 0.993, P = 0.013）和高总骨密度（TBMD）（60以上，OR = 0.974, 95% CI 0.954 ~ 0.994, P = 0.011）可降低衰弱风险。同样，不同部位的高前臂骨密度（FA-BMD）、高前臂超远端骨密度（UFA-BMD）和高跟骨骨密度也降低了虚弱的风险(OR = 0.966, 95% CI 0.936-0.996, P = 0.028；Or = 0.975, 95% ci 0.953-0.997, p = 0.029；Or = 0.981, 95% ci 0.967 ~ 0.995, p = 0.008)。在与肌肉减少症相关的特征中，左手握力、右手握力、阑尾瘦质量和步行速度都是虚弱的保护因素(OR = 0.788, 95% CI 0.721-0.862, P < 0.001；OR = 0.800, 95% CI 0.737-0.869, P < 0.001；Or = 0.955, 95% ci 0.937 ~ 0.974, p = 0.000；OR = 0.480, 95% CI 0.388-0.593, P < 0.001)， 60岁以上老年人握力低与虚弱呈显著正相关（OR = 1.168, 95% CI 1.059-1.289, P = 0.002）。骨关节炎和虚弱的MR结果显示特定关节部位与虚弱之间存在因果关系，包括KOA (OR = 1.086, 95% CI 1.017-1.160, P = 0.014), HOA （OR = 1.028, 95% CI 1.007-1.049, P = 0.009）和KOA/HOA (OR = 1.082, 95% CI 1.053-1.113, P = 0.000)，增加了虚弱的风险。结论骨骼肌减少症、骨关节炎和衰弱具有显著的因果关系，是衰弱的危险因素。因此，在临床实践中，应要求骨骼肌减少症和骨关节炎患者进行相关干预，以降低衰弱的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Clinical and Experimental Research 医学-老年医学

CiteScore

7.90

自引率

5.00%

发文量

283

审稿时长

1 months

期刊介绍： Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.