The association between dietary quality and biological aging: two-mediation analysis

IF 3.4 3区医学 Q2 GERIATRICS & GERONTOLOGY

Aging Clinical and Experimental Research Pub Date : 2025-04-21 DOI:10.1007/s40520-025-03038-z

Li-Sha Zeng, Yi-Ting Wu, Feng-Ping Zhang

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引用次数: 0

Abstract

Aims

Previous research has emphasized the firm link between diet and human health. However, the connection between comprehensive dietary patterns and biological aging has not been fully investigated. Our aim was to explore the potential association between dietary quality and delaying aging.

Methods

A total of 20,763 participants from the National Health and Nutrition Examination Survey were included in this cross-sectional study. The Mediterranean diet score (MDS), dietary approaches to stop hypertension index (DASHI), and healthy eating index 2020 (HEI2020) were utilized to assess dietary quality. Biological age was determined using the Klemera-Doubal method (KDM) biological age and phenotypic age (Levine’s), with the difference between biological age and chronological age representing aging acceleration. Independent relationships between dietary quality and biological aging were analyzed using weighted adjusted linear and logistic regression. Nonlinear trends and robustness of conclusions were examined. A secondary objective was to examine the role of Klotho and γ-glutamyltransferase (GGT) in mediation analyses.

Results

Dietary quality exhibited a negative association with biological aging, as evidenced by the interplay between three dietary patterns and two aging measures (The β of the linear regressions were all < 0). Restricted cubic splines confirmed the linear relationship, while subgroup interactions bolstered the stability of the results. Mediation analysis indicated that klotho and GGT partially mediated the association between dietary quality and biological aging (combined proportion mediation: 4.1-8.0%).

Conclusion

Dietary quality is closely associated with biological aging, with anti-aging proteins and oxidative stress potentially serving as underlying mediation mechanisms.

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饮食质量与生物衰老的关系：双中介分析

目的以往的研究强调了饮食与人体健康之间的紧密联系。然而，综合饮食模式与生物衰老之间的关系尚未得到充分研究。我们的目的是探索饮食质量和延缓衰老之间的潜在联系。方法从全国健康与营养检查调查中选取20,763名参与者进行横断面研究。采用地中海饮食评分（MDS）、饮食方法停止高血压指数（DASHI）和健康饮食指数2020 （HEI2020）来评估饮食质量。生物年龄采用klemera - double法（KDM）测定，生物年龄和表型年龄（Levine’s），生物年龄与实足年龄之差代表衰老加速。采用加权调整线性和逻辑回归分析饮食质量与生物衰老之间的独立关系。检验了结论的非线性趋势和稳健性。第二个目的是研究Klotho和γ-谷氨酰转移酶（GGT）在中介分析中的作用。结果膳食质量与生物衰老呈负相关，三种饮食模式与两种衰老指标之间存在相互作用（线性回归的β均为<； 0）。限制三次样条证实了线性关系，而亚群相互作用增强了结果的稳定性。中介分析表明，klotho和GGT在饲料质量与生物衰老之间具有部分中介作用（组合比例为4.1 ~ 8.0%）。结论膳食质量与生物衰老密切相关，抗衰老蛋白和氧化应激可能是其介导机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Clinical and Experimental Research 医学-老年医学

CiteScore

7.90

自引率

5.00%

发文量

283

审稿时长

1 months

期刊介绍： Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.