Ahmad Kassar MD , Nadia Chamoun MD , Romanos Haykal MD , Yaacoub Chahine MD , Miles Babb MD , Hala Al Yasiri MD , Tori Hensley BSc , Efstathia Andrikopoulou MD , Nazem Akoum MD, MS
{"title":"Atrial FDG uptake and atrial fibrillation: A systematic review and meta-analysis","authors":"Ahmad Kassar MD , Nadia Chamoun MD , Romanos Haykal MD , Yaacoub Chahine MD , Miles Babb MD , Hala Al Yasiri MD , Tori Hensley BSc , Efstathia Andrikopoulou MD , Nazem Akoum MD, MS","doi":"10.1016/j.hroo.2025.01.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Atrial inflammatory and metabolic derangements have been reported in patients with atrial fibrillation (AF).</div></div><div><h3>Objective</h3><div>We sought to evaluate the association of <sup>18</sup>F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) in the left and right atria and AF.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and meta-analysis, using the PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, of studies involving patients undergoing FDG-PET scans with reported atrial or ventricular uptake and outcomes of AF. Data were pooled and analyzed, and FDG uptake in AF and non-AF patients was compared using odds ratios (ORs).</div></div><div><h3>Results</h3><div>Six studies (4 retrospective, 1 prospective, and 1 case-control) were included in the meta-analysis of studies on patients not meeting diagnostic criteria for cardiac sarcoidosis (CS): 832 patients with a mean age of 67 years, 62% male, and 53% with hypertension. AF patients demonstrated higher odds of FDG uptake in the left atrium (pooled OR 14.50, 95% confidence interval 6.78–31.02; <em>P</em> < .0001, <em>I</em><sup>2</sup> = 0) and right atrium (pooled OR 51.98, 95% confidence interval 22.77–118.63, <em>P</em> < .0001, <em>I</em><sup>2</sup> = 0). Two studies on patients met diagnostic criteria for CS: one did not report atrial uptake and the other did not demonstrate a statistically significant association between right or left atrial uptake in AF patients.</div></div><div><h3>Conclusion</h3><div>In patients undergoing FDG-PET without meeting CS diagnostic criteria, FDG uptake in the atria was strongly associated with AF, suggesting altered metabolism or inflammation in AF pathophysiology and risk assessment.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 4","pages":"Pages 417-423"},"PeriodicalIF":2.5000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heart Rhythm O2","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666501825000078","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Atrial inflammatory and metabolic derangements have been reported in patients with atrial fibrillation (AF).
Objective
We sought to evaluate the association of 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) in the left and right atria and AF.
Methods
We conducted a systematic review and meta-analysis, using the PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, of studies involving patients undergoing FDG-PET scans with reported atrial or ventricular uptake and outcomes of AF. Data were pooled and analyzed, and FDG uptake in AF and non-AF patients was compared using odds ratios (ORs).
Results
Six studies (4 retrospective, 1 prospective, and 1 case-control) were included in the meta-analysis of studies on patients not meeting diagnostic criteria for cardiac sarcoidosis (CS): 832 patients with a mean age of 67 years, 62% male, and 53% with hypertension. AF patients demonstrated higher odds of FDG uptake in the left atrium (pooled OR 14.50, 95% confidence interval 6.78–31.02; P < .0001, I2 = 0) and right atrium (pooled OR 51.98, 95% confidence interval 22.77–118.63, P < .0001, I2 = 0). Two studies on patients met diagnostic criteria for CS: one did not report atrial uptake and the other did not demonstrate a statistically significant association between right or left atrial uptake in AF patients.
Conclusion
In patients undergoing FDG-PET without meeting CS diagnostic criteria, FDG uptake in the atria was strongly associated with AF, suggesting altered metabolism or inflammation in AF pathophysiology and risk assessment.