Organ doses for monkey anatomy models with different postures exposed to external photons

IF 2.6 3区工程技术 Q1 NUCLEAR SCIENCE & TECHNOLOGY

Nuclear Engineering and Technology Pub Date : 2025-04-21 DOI:10.1016/j.net.2025.103603

Jae W. Jung , Daniel D. Lee , Ae-Kyoung Lee , Hyung-Do Choi

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引用次数: 0

Abstract

Background

Understanding how external radiation from nuclear accidents or radiological attacks affects internal human anatomy is essential to accurately assess health risks and develop effective treatments. we calculated a library of organ dose conversion coefficients for anatomical monkey models in a standing, crawling, and squatting postures for the first time by using Monte Carlo radiation transport methods combined with anatomical monkey models.

Methods

We adopted previously published anatomical monkey models with three different postures: crawling, squatting, and standing. Radiation doses to a total of 39 organs and tissues were calculated using a general-purpose Monte Carlo radiation transport code, MCNP6.2, for the photon fields with 33 mono-energy bins ranging from 0.01 to 20 MeV in six different irradiation geometries: antero-posterior (AP), postero-anterior (PA), left lateral (LLAT), right lateral (RLAT), rotational (ROT), and isotropic (ISO).

Results

We found that the dose conversion coefficients derived from the standing posture may overestimate organ dose by up to 13-fold compared to the crawling position (e.g., large intestine in AP irradiation geometry). Irradiation geometry has the most substantial impact on organ doses in the crawling posture compared to squatting and standing postures. Average coefficients of variation over different organs were 51 % in crawling posture compared to 16 % and 17 % for standing and squatting postures, respectively.

Conclusion

In the present research, we employed the Monte Carlo radiation transport techniques to develop a library of organ dose conversion coefficients for an anatomical monkey model considering various postures and six distinct irradiation geometries. We found that the existing dose conversion coefficients for the standing posture may substantially overestimate organ doses for monkeys in more natural postures. Our data should be useful for understanding the impact of radiation events to human anatomy by evaluating the impact on monkey's anatomy as a surrogate.

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暴露于外部光子下不同姿势的猴子解剖模型的器官剂量

了解来自核事故或放射性攻击的外部辐射如何影响人体内部解剖结构，对于准确评估健康风险和开发有效的治疗方法至关重要。本文首次采用蒙特卡罗辐射输运方法结合解剖猴模型，计算了站立、爬行和蹲姿解剖猴模型的器官剂量转换系数库。方法采用已发表的三种不同姿势的猴子解剖模型：爬行、蹲立。利用通用蒙特卡罗辐射输运程序MCNP6.2，计算了在前后（AP）、后前（PA）、左外侧（LLAT）、右外侧（RLAT）、旋转（ROT）和各向异性（ISO） 6种不同辐照几何形状下，具有33个单能量箱的光子场对39个器官和组织的辐射剂量。结果我们发现，与爬行姿势相比，站立姿势的剂量转换系数可能高估器官剂量高达13倍（例如，AP照射几何中的大肠）。与蹲姿和站立姿相比，爬行姿势的照射几何形状对器官剂量的影响最大。不同器官的平均变异系数在爬行姿势为51%，而站立和蹲姿分别为16%和17%。在本研究中，我们采用蒙特卡罗辐射输运技术建立了一个考虑不同姿势和六种不同辐照几何形状的解剖猴模型的器官剂量转换系数库。我们发现现有的站立姿势的剂量转换系数可能大大高估了猴子在更自然的姿势下的器官剂量。我们的数据应该有助于理解辐射事件对人体解剖学的影响，通过评估对猴子的解剖学的影响作为替代品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nuclear Engineering and Technology 工程技术-核科学技术

CiteScore

4.80

自引率

7.40%

发文量

431

审稿时长

3.5 months

期刊介绍： Nuclear Engineering and Technology (NET), an international journal of the Korean Nuclear Society (KNS), publishes peer-reviewed papers on original research, ideas and developments in all areas of the field of nuclear science and technology. NET bimonthly publishes original articles, reviews, and technical notes. The journal is listed in the Science Citation Index Expanded (SCIE) of Thomson Reuters. NET covers all fields for peaceful utilization of nuclear energy and radiation as follows: 1) Reactor Physics 2) Thermal Hydraulics 3) Nuclear Safety 4) Nuclear I&C 5) Nuclear Physics, Fusion, and Laser Technology 6) Nuclear Fuel Cycle and Radioactive Waste Management 7) Nuclear Fuel and Reactor Materials 8) Radiation Application 9) Radiation Protection 10) Nuclear Structural Analysis and Plant Management & Maintenance 11) Nuclear Policy, Economics, and Human Resource Development