Nano TiO2 photocatalytic combined with optimized operating room care in postoperative infection after gynecological open abdominal surgery

IF 2.5 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

SLAS Technology Pub Date : 2025-04-10 DOI:10.1016/j.slast.2025.100291

Fang Yan , YuXuan Qi

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引用次数: 0

Abstract

Background

Disinfection of the operating room environment is essential to reduce the incidence of infection after laparotomy in obstetrics and gynecology. With the development of science and technology, nano-titanium dioxide (TiO2) photocatalytic technology has attracted much attention due to its high efficiency and low cost. To explore the effect of TiO2 photocatalytic technology and optimized operating room care in the prevention of postoperative infection in obstetrics and gynecology department.

Methods

Nano-TiO2 photocatalysts were prepared and characterized, and their bactericidal effect was analyzed. A total of 96 patients with gynecological open abdominal surgery were randomly divided into control group (CG) and observation group (BG), 48 cases in each group. The CG received routine care and the BG received optimized care. The wound healing rate, infection rate, serum immunoglobulin, and inflammatory factor levels were compared.

Results

The specific surface area of the nano-TiO2 photocatalyst was 75.1 m²/g, and the particle size was 16.6 nm, with rutile crystal structure. Compared with ultraviolet light, nano-TiO2 photocatalyst had better disinfection effect. Compared with the CG, the wound healing rate and IgG level were higher, and the infection rate, C-reactive protein, interleukin-6, and tumor necrosis factor-α were lower in the BG (P < 0.05).

Conclusion

The combination of nano-TiO2 photocatalytic disinfection and optimized nursing care resulted in a 16.66 % reduction in postoperative infections and a 14.58 % improvement in wound healing. This is associated with lower airborne pathogens (66.6 CFU/m³) and improved immune-inflammatory markers (↑IgG, ↓CRP/IL-6/TNF-α).

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纳米TiO2光催化联合优化的手术室护理在妇科开腹术后感染中的应用

背景消毒手术室环境对降低妇产科剖腹手术后感染的发生率至关重要。随着科学技术的发展，纳米二氧化钛（TiO2）光催化技术因其高效、低成本而备受关注。探讨TiO2光催化技术及优化的手术室护理在预防妇产科术后感染中的作用。方法制备纳米tio2光催化剂，对其进行表征，并对其杀菌效果进行分析。将96例妇科开腹手术患者随机分为对照组（CG）和观察组（BG），每组48例。CG组给予常规护理，BG组给予优化护理。比较两组创面愈合率、感染率、血清免疫球蛋白、炎症因子水平。结果纳米tio2光催化剂的比表面积为75.1 m2/g，粒径为16.6 nm，具有金红石型晶体结构。与紫外光相比，纳米tio2光催化剂具有更好的消毒效果。与CG组比较，BG组创面愈合率、IgG水平较高，感染率、c反应蛋白、白细胞介素-6、肿瘤坏死因子-α均较CG组低(P <；0.05)。结论纳米tio2光催化消毒配合优化护理，术后感染发生率降低16.66%，创面愈合率提高14.58%。这与降低空气传播病原体（66.6 CFU/m3）和改善免疫炎症标志物（↑IgG，↓CRP/IL-6/TNF-α）有关。

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来源期刊

SLAS Technology Computer Science-Computer Science Applications

CiteScore

6.30

自引率

7.40%

发文量

审稿时长

106 days

期刊介绍： SLAS Technology emphasizes scientific and technical advances that enable and improve life sciences research and development; drug-delivery; diagnostics; biomedical and molecular imaging; and personalized and precision medicine. This includes high-throughput and other laboratory automation technologies; micro/nanotechnologies; analytical, separation and quantitative techniques; synthetic chemistry and biology; informatics (data analysis, statistics, bio, genomic and chemoinformatics); and more.