Mechanisms of bone regeneration repair and potential and efficacy of small molecule drugs

IF 6.9 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Biomedicine & Pharmacotherapy Pub Date : 2025-04-21 DOI:10.1016/j.biopha.2025.118070

Ke Zhang , Hao Li , Tao Wang , Fanchao Li , Zhihong Xie , Hong Luo , Xuesong Zhu , Pengde Kang , Qinglin Kang , Zhang fei , Wuxun Peng

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引用次数: 0

Abstract

Bone regeneration and repair is a complex physiological process of bone formation. To date, existing research has greatly enhanced our understanding of bone regeneration and repair, achieving significant success in treating bone injuries. However, extensive bone defects, bone nonunion, and metabolic bone diseases remain incompletely solved challenges in modern medicine. With the emergence of High-Throughput Screening (HTS) technology, previous studies have identified numerous small molecule compounds with potential for inducing bone formation and enhancing bone metabolism. However, the effects of these small molecules on bone regeneration and repair through related signaling pathways have not been systematically elaborated. Therefore, in this literature review, we focus on summarizing the classical signaling pathways affecting bone regeneration and repair, as well as the research progress and applications of related small molecule drugs.

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骨再生修复的机制及小分子药物的潜力和疗效

骨再生与修复是一个复杂的骨形成生理过程。迄今为止，现有的研究大大提高了我们对骨再生和修复的认识，在治疗骨损伤方面取得了重大成功。然而，广泛的骨缺损、骨不连和代谢性骨疾病仍然是现代医学尚未完全解决的挑战。随着高通量筛选（High-Throughput Screening， HTS）技术的出现，以往的研究已经发现了许多具有诱导骨形成和促进骨代谢潜力的小分子化合物。然而，这些小分子通过相关信号通路对骨再生和修复的影响尚未得到系统阐述。因此，在本文的文献综述中，我们着重总结影响骨再生和修复的经典信号通路，以及相关小分子药物的研究进展和应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedicine & Pharmacotherapy 医学-药学

CiteScore

11.90

自引率

2.70%

发文量

1621

审稿时长

48 days

期刊介绍： Biomedicine & Pharmacotherapy stands as a multidisciplinary journal, presenting a spectrum of original research reports, reviews, and communications in the realms of clinical and basic medicine, as well as pharmacology. The journal spans various fields, including Cancer, Nutriceutics, Neurodegenerative, Cardiac, and Infectious Diseases.