Family history of diabetes mellitus and risk of colorectal cancer: A nationwide cohort study

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-04-17 DOI:10.1016/j.diabres.2025.112187

Zehui Chen , Elham Kharazmi , Qunfeng Liang , Kristina Sundquist , Jan Sundquist , Mahdi Fallah

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引用次数: 0

Abstract

Aims

Studies have shown the association between personal history of diabetes mellitus (DM type 1/2) and risk of colorectal cancer (CRC). This study aims to find the association between the family history of diabetes and CRC risk.

Methods

This large nationwide cohort study leveraged data from several Swedish nationwide registers (follow-up: 1964–2018) to compare the risk using standardized incidence ratio (SIR).

Results

11,784,567 individuals (668,348 with DM) were included and followed for up to 54 years (median = 28 years). Those with a personal history of DM had a 1.4-fold increased risk of CRC compared to those without DM (95 % CI: 1.39–1.45). However, the addition of a family history of DM in 1 FDR or ≥ 2 FDRs did not significantly alter the increased risk of early-onset or late-onset CRC.

Conclusion

Leveraging one of the world’s largest family-disease datasets, our cohort study confirmed that personal history of diabetes is associated with an increased risk of colorectal cancer, but we did not find an association between a family history of diabetes and risk of colorectal cancer.

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糖尿病家族史与结直肠癌风险：一项全国性队列研究

研究表明，糖尿病（1/2型糖尿病）的个人病史与结直肠癌（CRC）的风险之间存在关联。本研究旨在发现糖尿病家族史与结直肠癌风险之间的关系。方法：这项大型全国性队列研究利用了瑞典几个全国性登记册（随访：1964-2018）的数据，使用标准化发病率比（SIR）比较风险。结果纳入11,784,567人（其中668,348人患有糖尿病），随访时间长达54年（中位= 28年）。与没有糖尿病的患者相比，有糖尿病病史的患者患结直肠癌的风险增加了1.4倍（95% CI: 1.39-1.45）。然而，在1次FDR或≥2次FDR中增加糖尿病家族史并没有显著改变早发性或晚发性CRC的风险增加。利用世界上最大的家族疾病数据集之一，我们的队列研究证实了糖尿病个人病史与结直肠癌风险增加有关，但我们没有发现糖尿病家族史与结直肠癌风险之间的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.