Multimodal Synergistic Antimicrobial Activity of the Copper-Doped and Oxygen-Defective In Situ Nanocoating on Medical Titanium

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2025-04-10 DOI:10.1021/acsabm.5c0037610.1021/acsabm.5c00376

Leizi Chi, Jinteng Qi, Zhuo Ma*, Zeshuai Zhang, Yunfeng Qiu*, Tiedong Sun* and Shaoqin Liu*,

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Abstract

To combat escalating antibiotic resistance in titanium implant-associated infections, oxygen-vacancy-rich polydopamine/TiCu nanocoating (PDA/p-TiCu-300 °C) was developed on medical-grade titanium, uniquely enabling synergistic photothermal (PTT), photodynamic (PDT), and sonodynamic (SDT) antimicrobial strategies. Unlike previous dual-modal approaches, this trimodal strategy, activated by near-infrared light and ultrasound, achieved exceptional broad-spectrum bactericidal efficacy against both Escherichia coli (99.19% killing) and Staphylococcus aureus (95.03% killing) via enhanced reactive oxygen species (ROS) generation and membrane disruption. The engineered oxygen vacancies within the PDA/p-TiCu-300 °C nanocoating significantly boosted ROS production, outperforming conventional photocatalytic materials. Crucially, the nanocoatings demonstrated excellent in vitro cytocompatibility. This PTT–PDT–SDT platform exhibits synergistic multimodal bactericidal activity, overcoming the limitations of existing strategies and representing a paradigm shift in implant surface modification with significant translational potential against severe infections.

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掺铜和缺氧原位纳米涂层在医用钛上的多模式协同抗菌活性

为了对抗钛植入物相关感染中不断升级的抗生素耐药性，在医用级钛上开发了富氧空位的聚多巴胺/TiCu纳米涂层（PDA/p-TiCu-300°C），独特地实现了光热（PTT）、光动力（PDT）和声动力（SDT）协同抗菌策略。与之前的双峰方法不同，这种由近红外光和超声波激活的三峰策略，通过增强活性氧（ROS）的产生和膜破坏，对大肠杆菌（99.19%）和金黄色葡萄球菌（95.03%）均取得了出色的广谱杀菌效果。在PDA/p-TiCu-300°C纳米涂层内的工程氧空位显著提高了ROS的产量，优于传统的光催化材料。至关重要的是，纳米涂层表现出优异的体外细胞相容性。这种PTT-PDT-SDT平台具有协同的多模态杀菌活性，克服了现有策略的局限性，代表了种植体表面修饰的范式转变，具有对抗严重感染的显著转化潜力。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.