Cytoprotective Nanoencapsulation of Probiotic Cells within Fe3+-Phytic Acid Nanoshells

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Langmuir Pub Date : 2025-04-18 DOI:10.1021/acs.langmuir.5c00722

Sang Yeong Han, Nayoung Kim, Duc Tai Nguyen, Seoin Yang, Eunhye K. Kang, Ghanyatma Adi Baskoro, Sang-Hee Lee, Kyung-Bok Lee, Beom Jin Kim, Insung S. Choi

引用次数: 0

Abstract

Probiotic oral delivery is challenged by harsh gastrointestinal conditions and environmental stressors in the body. This study presents the construction of durable nanoshells composed of an Fe³⁺-phytic acid metal–organic complex around individual probiotic cells, providing exceptional cytoprotective properties, in single-cell nanoencapsulation. Nanoencapsulated Levilactobacillus brevis maintains high viability under simulated gastric fluid and the antibiotic tetracycline. The Fe³⁺-phytic acid nanoshells provide an effective platform for improving the viability and functionality of probiotics in therapeutic and nutritional applications.

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Fe3+-植酸纳米壳内益生菌细胞的细胞保护纳米包封

益生菌的口服递送受到体内恶劣胃肠道条件和环境压力的挑战。本研究提出了在单个益生菌细胞周围构建由Fe3+-植酸金属-有机复合物组成的耐用纳米壳，在单细胞纳米封装中提供卓越的细胞保护性能。纳米囊化短乳杆菌在模拟胃液和抗生素四环素下保持较高的活力。Fe3+-植酸纳米壳为提高益生菌在治疗和营养方面的活性和功能提供了有效的平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Langmuir 化学-材料科学：综合

CiteScore

6.50

自引率

10.30%

发文量

1464

审稿时长

2.1 months

期刊介绍： Langmuir is an interdisciplinary journal publishing articles in the following subject categories: Colloids: surfactants and self-assembly, dispersions, emulsions, foams Interfaces: adsorption, reactions, films, forces Biological Interfaces: biocolloids, biomolecular and biomimetic materials Materials: nano- and mesostructured materials, polymers, gels, liquid crystals Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do? Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*. This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).