Mechanisms of Glucocorticoid Resistance in Nonclassical T Helper Populations Th17.1/Ex-Th17

IF 2.3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Elena M. Kuklina
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引用次数: 0

Abstract

The nonclassical population of Th1-polarized Th17 lymphocytes (Th17.1/ex-Th17) is currently in the focus of researchers’ attention. These cells possess a unique proinflammatory potential and ability to penetrate blood-tissue barriers and play a key role in the pathogenesis of many inflammatory diseases, primarily autoimmune ones. Th1-polarized Th17 lymphocytes prevail in the autoimmune lesion foci and are considered to be a promising therapeutic target in these pathologies. At the same time, recent studies have shown another distinctive feature of Th1-polarized Th17 – their selective resistance to glucocorticoids. Since glucocorticoids are the first-line drugs for the treatment of the autoimmune disease exacerbation, understanding the causes of this phenomenon is crucial for predicting patients’ response to therapy and improving the treatment effectiveness. This review analyzes the mechanisms of drug resistance of Th1-polarized Th17 cells, compares these mechanisms with those typical of nonpathogenic classical Th17 cells, and discusses the role of glucocorticoid resistance in the body’s response to glucocorticoid therapy.

非经典T辅助群体糖皮质激素抗性机制Th17.1/Ex-Th17
th1极化Th17淋巴细胞的非经典群体(Th17.1/前Th17)是目前研究人员关注的焦点。这些细胞具有独特的促炎潜能和穿透血液组织屏障的能力,在许多炎症性疾病(主要是自身免疫性疾病)的发病机制中发挥关键作用。th1极化的Th17淋巴细胞在自身免疫性病变灶中普遍存在,被认为是这些病理中有希望的治疗靶点。同时,最近的研究显示th1极化Th17的另一个显著特征-它们对糖皮质激素的选择性抗性。由于糖皮质激素是治疗自身免疫性疾病恶化的一线药物,了解这一现象的原因对于预测患者对治疗的反应和提高治疗效果至关重要。本文分析了th1极化Th17细胞的耐药机制,并将其与典型的非致病性经典Th17细胞的耐药机制进行了比较,探讨了糖皮质激素耐药在机体对糖皮质激素治疗反应中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biochemistry (Moscow)
Biochemistry (Moscow) 生物-生化与分子生物学
CiteScore
4.70
自引率
3.60%
发文量
139
审稿时长
2 months
期刊介绍: Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).
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