Exploring the pathogenic and transmission characteristics of JN.1 in golden hamsters based on different attack methods

IF 2.8 3区医学 Q3 VIROLOGY

Virology Pub Date : 2025-04-17 DOI:10.1016/j.virol.2025.110548

Ruixue Liu , Fang Song , Li Sun , Fang Yan , Qiushi Jin , Fang Yan , Xianzhu Xia , Xuefeng Wang , Yuwei Gao

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引用次数: 0

Abstract

Since its emergence at the end of 2023, the JN.1 variant of COVID-19 has become the dominant strain globally. Currently, its characteristics in related animal models remain largely unknown. The results indicate that JN.1 can cause weight loss, viral load, viral titer, and histopathological changes in golden hamsters via intranasal and intragastric inoculation methods, with intranasal inoculation leading to faster viral replication. Interestingly, both viral load and viral titer of JN.1 are significantly lower than those of its parental strains BA.2 and XBB EG.5.1. A comparison of hematological data from the two inoculation methods was also consistent with previous findings. This highlights the importance of the infection route in studying the virus's progression and characteristics. In direct transmission studies of JN.1, the minimum time for virus transmission was 24 h, while XBB EG.5.1 could transmit the virus in as little as 6 h. Finally, the in vivo adaptability of JN.1 was investigated, with XBB EG.5.1 showing a more apparent adaptability advantage. Therefore, compared with EG.5.1, the pathogenicity and transmissibility of JN.1 are significantly weakened.

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来源期刊

Virology 医学-病毒学

CiteScore

6.00

自引率

0.00%

发文量

157

审稿时长

50 days

期刊介绍： Launched in 1955, Virology is a broad and inclusive journal that welcomes submissions on all aspects of virology including plant, animal, microbial and human viruses. The journal publishes basic research as well as pre-clinical and clinical studies of vaccines, anti-viral drugs and their development, anti-viral therapies, and computational studies of virus infections. Any submission that is of broad interest to the community of virologists/vaccinologists and reporting scientifically accurate and valuable research will be considered for publication, including negative findings and multidisciplinary work.Virology is open to reviews, research manuscripts, short communication, registered reports as well as follow-up manuscripts.