Proteomics in decoding cancer: A review

IF 3.2 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2025-04-10 DOI:10.1016/j.cca.2025.120302

Elaheh Gheybi , Pejman Hosseinzadeh , Vahid Tayebi-Khorrami , Mehdi Rostami , Mohammad Soukhtanloo

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引用次数: 0

Abstract

Cancer remains the second leading cause of death worldwide, posing a significant global health challenge. Extensive research has revealed common biological characteristics across cancer cells, forming the foundation for developing innovative diagnostic and therapeutic strategies. To better understand these shared traits, advanced measurement technologies are critical. Proteomics, the large-scale study of proteins and their functions, has emerged as a transformative tool for uncovering the complexities of cancer biology. This approach provides an in-depth view of cellular activities and protein interactions, offering unprecedented insights into cancer progression and treatment. Unlike traditional methods that investigate specific pathways in isolation, proteomics enables simultaneous analysis of thousands of proteins, generating a comprehensive understanding of cancer biology. This review explores the mechanisms underlying proteomics, its application to understanding cancer hallmarks, and its potential to transform clinical approaches. By examining proteomics’ role in metastasis, angiogenesis, proliferation, and resistance mechanisms, this study highlights its contributions to cancer diagnosis, treatment, and personalized medicine. Additionally, prospects in integrating proteomics with other −omics fields and advancements in computational analysis will be discussed. This work aims to illuminate the path toward more effective, precise, and individualized cancer care through proteomics innovations.

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蛋白质组学在癌症解码中的研究进展

癌症仍然是全球第二大死亡原因，对全球健康构成重大挑战。广泛的研究揭示了癌细胞的共同生物学特征，为开发创新的诊断和治疗策略奠定了基础。为了更好地理解这些共同特征，先进的测量技术至关重要。蛋白质组学是对蛋白质及其功能的大规模研究，已经成为揭示癌症生物学复杂性的变革性工具。这种方法提供了细胞活动和蛋白质相互作用的深入视图，为癌症进展和治疗提供了前所未有的见解。与传统方法不同，蛋白质组学可以同时分析数千种蛋白质，从而对癌症生物学产生全面的了解。这篇综述探讨了蛋白质组学的潜在机制，它在理解癌症特征方面的应用，以及它改变临床方法的潜力。通过研究蛋白质组学在转移、血管生成、增殖和耐药机制中的作用，本研究突出了其在癌症诊断、治疗和个性化医疗方面的贡献。此外，还将讨论蛋白质组学与其他组学领域整合的前景以及计算分析的进展。这项工作旨在通过蛋白质组学的创新，为更有效、精确和个性化的癌症治疗指明道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.