Evaluating the impact of Matrilin-1 gene polymorphisms on mandibular prognathism: A meta-analysis

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2025-04-18 DOI:10.1016/j.jobcr.2025.03.019

Pooja Kurmi , Prasad Nalabothu , Shubhasmita Sahoo , Henu Kumar Verma , Srinivas Gosla Reddy , L.V.K.S. Bhaskar

{"title":"Evaluating the impact of Matrilin-1 gene polymorphisms on mandibular prognathism: A meta-analysis","authors":"Pooja Kurmi , Prasad Nalabothu , Shubhasmita Sahoo , Henu Kumar Verma , Srinivas Gosla Reddy , L.V.K.S. Bhaskar","doi":"10.1016/j.jobcr.2025.03.019","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Matrilin-1 was shown to regulate the formation of cartilage matrix and to promote chondrocyte differentiation. This meta-analysis aims to synthesize evidence regarding the link between mandibular prognathism (MP) risk and the polymorphisms in the MATN1 gene.</div></div><div><h3>Materials and methods</h3><div>Relevant publications were retrieved by searching the PubMed, Web of Science, and Google Scholar databases. The association between MP and the MATN1 gene polymorphisms (rs20566, rs1065755<strong>)</strong> was assessed by calculating odds ratios (ORs) and 95 % CIs. Between studies, heterogeneity was identified using the Cochrane Q test and I<sup>2</sup> statistics. To assess the robustness of the meta-analysis sensitivity analysis was performed. The web tool MetaGenyo was used to conduct a meta-analysis.</div></div><div><h3>Results</h3><div>A total of four Asian and one Caucasian study were eventually taken for meta-analysis. Overall, the MATN1 rs20566 and rs1065755 polymorphisms are not associated with elevated risk of MP (rs20566 AA + AG versus GG OR = 1.35, 95 % CI = 0.32–5.67; rs1065755 TT + CT versus CC OR = 2.02, 95 % CI = 0.87–4.68). The degree of heterogeneity is found to be large for the MATN1 polymorphisms (for rs20566, I<sup>2=</sup>89 %, and for rs1065755, I<sup>2=</sup>60 %).</div></div><div><h3>Conclusions</h3><div>In conclusion, this meta-analysis did not provide evidence for the link between MATN1 polymorphisms and MP. However, the results conflict with the biological plausibility that matrilin-1 levels modulate cartilage development. Therefore, careful interpretation is needed, and further research is recommended.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 691-695"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of oral biology and craniofacial research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221242682500082X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Matrilin-1 was shown to regulate the formation of cartilage matrix and to promote chondrocyte differentiation. This meta-analysis aims to synthesize evidence regarding the link between mandibular prognathism (MP) risk and the polymorphisms in the MATN1 gene.

Materials and methods

Relevant publications were retrieved by searching the PubMed, Web of Science, and Google Scholar databases. The association between MP and the MATN1 gene polymorphisms (rs20566, rs1065755) was assessed by calculating odds ratios (ORs) and 95 % CIs. Between studies, heterogeneity was identified using the Cochrane Q test and I² statistics. To assess the robustness of the meta-analysis sensitivity analysis was performed. The web tool MetaGenyo was used to conduct a meta-analysis.

Results

A total of four Asian and one Caucasian study were eventually taken for meta-analysis. Overall, the MATN1 rs20566 and rs1065755 polymorphisms are not associated with elevated risk of MP (rs20566 AA + AG versus GG OR = 1.35, 95 % CI = 0.32–5.67; rs1065755 TT + CT versus CC OR = 2.02, 95 % CI = 0.87–4.68). The degree of heterogeneity is found to be large for the MATN1 polymorphisms (for rs20566, I²⁼89 %, and for rs1065755, I²⁼60 %).

Conclusions

In conclusion, this meta-analysis did not provide evidence for the link between MATN1 polymorphisms and MP. However, the results conflict with the biological plausibility that matrilin-1 levels modulate cartilage development. Therefore, careful interpretation is needed, and further research is recommended.

Abstract Image

查看原文本刊更多论文

评估Matrilin-1基因多态性对下颌前伸症的影响：一项荟萃分析

matrilin -1可调节软骨基质的形成，促进软骨细胞分化。本荟萃分析旨在综合有关下颌前突（MP）风险与MATN1基因多态性之间联系的证据。材料和方法通过检索PubMed、Web of Science和b谷歌Scholar数据库检索相关出版物。通过计算比值比（ORs）和95% ci来评估MP与MATN1基因多态性（rs20566、rs1065755）之间的关联。在研究之间，使用Cochrane Q检验和I2统计来确定异质性。为了评估meta分析的稳健性，进行了敏感性分析。使用网络工具MetaGenyo进行meta分析。结果4项亚洲研究和1项高加索研究最终被纳入meta分析。总体而言，MATN1 rs20566和rs1065755多态性与MP风险升高无关(rs20566 AA + AG vs GG OR = 1.35, 95% CI = 0.32-5.67；TT + CT与CC OR = 2.02, 95% CI = 0.87-4.68)。发现MATN1多态性的异质性程度很大（rs20566, I2= 89%, rs1065755, I2= 60%）。结论本荟萃分析并未提供MATN1多态性与MP之间联系的证据。然而，这些结果与matrilin-1水平调节软骨发育的生物学合理性相冲突。因此，需要仔细解读，并建议进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.