EEG markers of cognitive performance in bipolar disorder – A systematic review

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews Pub Date : 2025-04-14 DOI:10.1016/j.neubiorev.2025.106157

Anna Tröger , Pietro Carmellini , Dimosthenis Tsapekos , Joachim Gross , Allan H. Young , Rebecca Strawbridge , Philipp Ritter

{"title":"EEG markers of cognitive performance in bipolar disorder – A systematic review","authors":"Anna Tröger , Pietro Carmellini , Dimosthenis Tsapekos , Joachim Gross , Allan H. Young , Rebecca Strawbridge , Philipp Ritter","doi":"10.1016/j.neubiorev.2025.106157","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>People with bipolar disorder (BD) may experience impairing cognitive deficits, even in remission. Electroencephalographic (EEG) measures can depict neurophysiological activity with high temporal resolution. They could therefore be an adequate method to pinpoint the cognitive impairments in BD, facilitating understanding of when exactly the cognitive processing is disrupted and what neurophysiological systems are involved. In the absence of a previous literature examination, this systematic review aimed to synthesize the evidence of associations between EEG and cognitive measures to identify electrophysiological markers of cognitive performance in BD.</div></div><div><h3>Methods</h3><div>A systematic search across PubMed, EMBASE, APA PsycInfo and Cochrane Library until November 2023 was undertaken to identify studies in which a direct correlation between any continuous EEG measure and any continuous cognitive measure in participants with BD was reported. A narrative synthesis approach was used to present the identified correlations, across five cognitive (attention and processing speed, working memory, episodic memory, executive function, and intellectual capacity) and four EEG domains (event-related potentials (ERP), spectral, connectivity and other measures).</div></div><div><h3>Results</h3><div>A total of 16 articles describing 15 studies were included in the review. Six studies identified significant correlations. Most significant correlations were reported between ERP measures and attention and processing speed performance, several between ERP measures and executive functioning and one within the working memory and the intellectual capacity domain respectively. However, most of the identified significant correlations were conflicting within (different measures or mood states) and across studies with no consistent significant correlation across studies. The majority of identified correlations were non-significant.</div></div><div><h3>Conclusions</h3><div>As yet no robust EEG markers of cognitive performance in people with BD are known. This review highlights the heterogeneity in measures and participant characteristics between studies and the need for standardization. Further studies with homogeneous methods and participant groups may help to establish consistent associations.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"173 ","pages":"Article 106157"},"PeriodicalIF":7.5000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroscience and Biobehavioral Reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0149763425001575","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

People with bipolar disorder (BD) may experience impairing cognitive deficits, even in remission. Electroencephalographic (EEG) measures can depict neurophysiological activity with high temporal resolution. They could therefore be an adequate method to pinpoint the cognitive impairments in BD, facilitating understanding of when exactly the cognitive processing is disrupted and what neurophysiological systems are involved. In the absence of a previous literature examination, this systematic review aimed to synthesize the evidence of associations between EEG and cognitive measures to identify electrophysiological markers of cognitive performance in BD.

Methods

A systematic search across PubMed, EMBASE, APA PsycInfo and Cochrane Library until November 2023 was undertaken to identify studies in which a direct correlation between any continuous EEG measure and any continuous cognitive measure in participants with BD was reported. A narrative synthesis approach was used to present the identified correlations, across five cognitive (attention and processing speed, working memory, episodic memory, executive function, and intellectual capacity) and four EEG domains (event-related potentials (ERP), spectral, connectivity and other measures).

Results

A total of 16 articles describing 15 studies were included in the review. Six studies identified significant correlations. Most significant correlations were reported between ERP measures and attention and processing speed performance, several between ERP measures and executive functioning and one within the working memory and the intellectual capacity domain respectively. However, most of the identified significant correlations were conflicting within (different measures or mood states) and across studies with no consistent significant correlation across studies. The majority of identified correlations were non-significant.

Conclusions

As yet no robust EEG markers of cognitive performance in people with BD are known. This review highlights the heterogeneity in measures and participant characteristics between studies and the need for standardization. Further studies with homogeneous methods and participant groups may help to establish consistent associations.

查看原文本刊更多论文

双相情感障碍认知能力的脑电图标记--系统综述

双相情感障碍（BD）患者可能会经历认知缺陷的损害，即使在缓解期。脑电图（EEG）测量能够以高时间分辨率描述神经生理活动。因此，它们可能是一种适当的方法来查明双相障碍中的认知障碍，有助于了解认知过程何时被破坏以及涉及哪些神经生理系统。在缺乏文献研究的情况下，本系统综述旨在综合脑电图和认知测量之间关联的证据，以确定bd中认知表现的电生理标记。APA PsycInfo和Cochrane Library在2023年11月之前进行了一项研究，以确定在双相障碍参与者中任何连续脑电图测量和任何连续认知测量之间存在直接相关性的研究。采用叙事综合的方法，在五个认知领域（注意力和处理速度、工作记忆、情景记忆、执行功能和智力）和四个脑电领域（事件相关电位（ERP）、频谱、连通性和其他测量）中呈现出确定的相关性。结果共纳入16篇文献，共15项研究。六项研究发现了显著的相关性。ERP测量与注意力和处理速度表现之间存在显著的相关性，ERP测量与执行功能之间存在显著的相关性，ERP测量与工作记忆和智力能力之间存在显著的相关性。然而，大多数确定的显著相关性在研究内部（不同的测量或情绪状态）和研究之间是相互冲突的，在研究之间没有一致的显著相关性。大多数确定的相关性是不显著的。结论目前尚不清楚双相障碍患者认知表现的EEG指标。这篇综述强调了研究之间测量方法和参与者特征的异质性以及标准化的必要性。采用同质方法和参与者群体的进一步研究可能有助于建立一致的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neuroscience and Biobehavioral Reviews 医学-行为科学

CiteScore

14.20

自引率

3.70%

发文量

466

审稿时长

6 months

期刊介绍： The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.