Cobalt-Catalyzed Enantioselective Alkenylative Cyclization of 1,6-Allenynes

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-04-17 DOI:10.1002/adsc.202500022

Tao Wang, Ji-Xun Guan, Yun-Xuan Tan, Ping Tian

引用次数: 0

Abstract

Transition metal-catalyzed cascade cyclization of allenynes is regarded as an efficient approach for the synthesis of versatile cyclic frameworks. However, catalytic asymmetric cascade cyclizations of allenynes are still uncommon. Herein, we present the first cobalt-catalyzed enantioselective alkenylative cyclization of 1,6-allenynes with readily available alkenylboronic acids, providing five-membered carbo- and heterocycles with high efficiency (up to 97% yield), broad substrate scope, and moderate to good enantioselectivities (up to 95:5 er).

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钴催化的 1,6-Allenynes 对映体选择性烯丙基环化反应

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.