Secreted proteins in treating metabolic-dysfunction associated steatotic liver disease: from bench towards bedside.

IF 13.6 1区生物学 Q1 CELL BIOLOGY

Protein & Cell Pub Date : 2025-04-17 DOI:10.1093/procel/pwaf027

Yeping Huang,Bin Liu,Cheng Hu,Yan Lu

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引用次数: 0

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a global epidemic, yet effective pharmacological treatments remain limited. Secreted proteins play diverse roles in regulating glucose and lipid metabolism, and their dysregulation is implicated in the development of various metabolic diseases, including MASLD. Therefore, targeting secreted proteins and modulating associated signaling pathways represents a promising therapeutic strategy for MASLD. In this review, we summarize recent findings on the roles of emerging families of secreted proteins in MASLD and related metabolic disorders. These include the orosomucoid (ORM) family, secreted acidic cysteine rich glycoprotein (SPARC) family, neuregulin (Nrg) family, growth differentiation factor (GDF) family, interleukin (IL) family, fibroblast growth factor (FGF) family, bone morphogenic protein (BMP) family, as well as isthmin-1 (Ism1) and mesencephalic astrocyte-derived neurotrophic factor (MANF). The review highlights their impact on glucose and lipid metabolism and discusses the clinical potential of targeting these secreted proteins as a therapeutic approach for MASLD.

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分泌蛋白治疗代谢功能障碍相关的脂肪变性肝病：从实验室到床边。

代谢功能障碍相关脂肪变性肝病（MASLD）已成为一种全球性流行病，但有效的药物治疗仍然有限。分泌蛋白在调节糖脂代谢中发挥多种作用，其失调与包括MASLD在内的多种代谢性疾病的发生有关。因此，靶向分泌蛋白并调节相关信号通路是治疗MASLD的一种很有前景的治疗策略。在这篇综述中，我们总结了新发现的分泌蛋白家族在MASLD和相关代谢疾病中的作用。其中包括orosomucoid （ORM）家族，分泌酸性富半胱氨酸糖蛋白（SPARC）家族，神经调节蛋白（Nrg）家族，生长分化因子（GDF）家族，白细胞介素（IL）家族，成纤维细胞生长因子（FGF）家族，骨形态发生蛋白（BMP）家族，以及isthin -1 （Ism1）和中脑星形细胞源性神经营养因子（MANF）。这篇综述强调了它们对葡萄糖和脂质代谢的影响，并讨论了靶向这些分泌蛋白作为MASLD治疗方法的临床潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Protein & Cell CELL BIOLOGY-

CiteScore

24.00

自引率

0.90%

发文量

1029

审稿时长

6-12 weeks

期刊介绍： Protein & Cell is a monthly, peer-reviewed, open-access journal focusing on multidisciplinary aspects of biology and biomedicine, with a primary emphasis on protein and cell research. It publishes original research articles, reviews, and commentaries across various fields including biochemistry, biophysics, cell biology, genetics, immunology, microbiology, molecular biology, neuroscience, oncology, protein science, structural biology, and translational medicine. The journal also features content on research policies, funding trends in China, and serves as a platform for academic exchange among life science researchers.