Front Cover: Expanding the Variety of Pyridinium-Based Bis-QACs with Antimicrobial Properties: Investigation into Linker Structure-Activity Correlation (ChemMedChem 8/2025)

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-04-17 DOI:10.1002/cmdc.202580801

Nikita A. Frolov, Alexander A. Tyutin, Alexandra N. Tyurina, Mary A. Seferyan, Elena V. Detusheva, Elizabeth Son, Evgeniya A. Saverina, Anatoly N. Vereshchagin

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Abstract

This illustration depicts the destruction of a bacterial biofilm by molecules QACs. The formation of biofilms significantly increases bacterial resistance to antimicrobial agents, making eradication difficult and reducing the effectiveness of conventional treatments. The “QAC superheroes” symbolize the action of these antimicrobial agents, penetrating the protective biofilm matrix, killing bacteria and disrupting its structure. These findings will serve as a good basis for further studies of QACs architectures as highly effective biocides. More details can be found in article 10.1002/cmdc.202400972 by Anatoly N. Vereshchagin and co-workers.

Abstract Image

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封面：扩展具有抗菌性能的吡啶基双qacs的种类：连接子结构-活性相关性的研究（ChemMedChem 8/2025）

这幅插图描绘了QACs分子对细菌生物膜的破坏。生物膜的形成大大增加了细菌对抗菌剂的耐药性，使根除变得困难，并降低了常规治疗的有效性。“QAC超级英雄”象征着这些抗菌剂的作用，它们穿透保护性生物膜基质，杀死细菌并破坏其结构。这些发现将为QACs结构作为高效杀菌剂的进一步研究奠定良好的基础。更多细节可以在10.1002/cmdc中找到。Anatoly N. Vereshchagin和他的同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.