Nanoparticles Combining Host-Directed Therapeutics and Antibiotics to Boost Bacterial Killing and Overall Survival of Zebrafish Embryos Infected with Mycobacterium Marinum (Adv. Therap. 4/2025)

Abstract

Tuberculosis (TB) is a highly complex, heterogenous and thus hardly curable infection caused by the Mycobacterium Tuberculosis. Since the therapeutic efficacy of antibiotics and vaccines remains limited, TB remains a global thread. In article 2400174, Andrew M. Thompson, Matthias Barz, and co-workers demonstrate that the combination of antibiotics and host directed therapeutics in polypeptides(o)ide micelles can completely eradicate bacterial infections in cell and zebrafish models of tuberculosis.