Biological Effects of Dietary Restriction on Alzheimer's Disease: Experimental and Clinical Investigations

IF 4.8 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2025-04-17 DOI:10.1111/cns.70392

Zijiao Liu, Jun Zhang, Fei Jiang, Cong Liu, Yaping Shao, Weidong Le

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引用次数: 0

Abstract

Backgrounds

Dementia can impose a heavy economic burden on both society and families. Alzheimer's disease (AD), the most prevalent form of dementia, is a complex neurodegenerative disease characterized by the abnormal deposition of extracellular amyloid β-protein (Aβ) and the aggregation of intracellular Tau protein to form neurofibrillary tangles (NFTs). Given the limited efficacy of pharmacological treatment, scientists have already paid more attention to non-pharmacological strategies, including dietary restriction (DR). DR refers to a nutritional paradigm aimed at promoting overall health by modifying the balance between energy consumption and expenditure. Studies have demonstrated that DR effectively extends the healthy lifespan, delays the aging process, and achieves promising results in the prevention and treatment of AD in preclinical studies.

Methods

In this review we collected related studies and viewpoints by searching on PubMed database using the keywords. Most of the citations were published between 2015 and 2025. A few older literatures were also included due to their relevance and significance in this field.

Results

We first provide a concise overview of the current therapeutic and preventive strategies for AD. Then, we introduce several specific DR protocols and their favorable effects on AD. Furthermore, the potential mechanisms underlying the benefits of DR on AD are discussed. Finally, we briefly highlight the role of DR in maintaining brain health.

Conclusion

This review may offer valuable insights into the development of innovative non-pharmacological strategies for AD treatment.

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饮食限制对阿尔茨海默病的生物学效应：实验和临床研究

痴呆症会给社会和家庭带来沉重的经济负担。阿尔茨海默病（AD）是最常见的痴呆形式，是一种复杂的神经退行性疾病，其特征是细胞外淀粉样β蛋白（a β）异常沉积和细胞内Tau蛋白聚集形成神经原纤维缠结（nft）。鉴于药物治疗的效果有限，科学家们已经更多地关注非药物策略，包括饮食限制（DR）。DR指的是一种营养模式，旨在通过调整能量消耗和支出之间的平衡来促进整体健康。研究表明，DR能有效延长健康寿命，延缓衰老进程，在临床前研究中对AD的防治取得了可喜的成果。方法通过关键词检索PubMed数据库，收集相关研究和观点。大多数引用发表于2015年至2025年之间。由于其在该领域的相关性和重要性，也包括了一些较早的文献。我们首先简要概述了当前AD的治疗和预防策略。然后，我们介绍了几种具体的DR协议及其对AD的有利影响。此外，本文还讨论了DR对AD有益的潜在机制。最后，我们简要地强调了DR在维持大脑健康中的作用。结论本综述为开发创新的AD非药物治疗策略提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.