Switchable Site‐Selectivite Direct Acetoxylation of Pyrazolones

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-04-01 DOI:10.1002/ajoc.202400808

Tanakorn Kittikool , Tarm Viriyanukul , Kunita Phakdeeyothin , Sirilata Yotphan

引用次数: 0

Abstract

Site‐selective direct acetoxylation of pyrazolones was accomplished by utilizing an easy‐to‐handle (diacetoxyiodo)benzene (PIDA) as the sole acetoxylating reagent. In the presence of Pd(OAc)₂ catalyst, the 4‐acetoxylated pyrazolone product was exclusively formed. Meanwhile, in the absence of Pd(OAc)₂, the pyrazolone methyl acetate product was obtained over the Csp²−H bond functionalization. Both approaches have been successfully applied to various pyrazolone substrates, giving the corresponding products in moderate to high yields under mild conditions.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.