Synthesis of Polyfunctional Indazoles via Novel Rearrangement of Isatin Derivatives

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-02-02 DOI:10.1002/ajoc.202400656

Elena Bezsonova, Viktor Tafeenko, Sergey Sosonyuk, Natalia Lozinskaya

引用次数: 0

Abstract

In this work we present a new method for indazole synthesis through the unexpected rearrangement of various 7-nitroisatins during the reaction with hydrazine hydrate. The new pyrazole cycle is formed via direct metal-free C−H amination. We demonstrate the limitations of the discovered approach and several accessible methods for functionalization of the compounds to obtain novel indazole derivatives.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.