Lipid Droplet in Lipodystrophy and Neurodegeneration

IF 2.4 4区 生物学 Q4 CELL BIOLOGY
Priyatama Behera, Monalisa Mishra
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引用次数: 0

Abstract

Lipid droplets are ubiquitous yet distinct intracellular organelles that are gaining attention for their uses outside of energy storage. Their formation, role in the physiological function, and the onset of the pathology have been gaining attention recently. Their structure, synthesis, and turnover play dynamic roles in both lipodystrophy and neurodegeneration. Factors like development, aging, inflammation, and cellular stress regulate the synthesis of lipid droplets. The biogenesis of lipid droplets has a critical role in reducing cellular stress. Lipid droplets, in response to stress, sequester hazardous lipids into their neutral lipid core, preserving energy and redox balance while guarding against lipotoxicity. Thus, the maintenance of lipid droplet homeostasis in adipose tissue, CNS, and other body tissues is essential for maintaining organismal health. Insulin resistance, hypertriglyceridemia, and lipid droplet accumulation are the severe metabolic abnormalities that accompany lipodystrophy-related fat deficit. Accumulation of lipid droplets is detected in almost all neurodegenerative diseases like Alzheimer's, Parkinson's, Huntington's, and Hereditary spastic paraplegia. Hence, the regulation of lipid droplets can be used as an alternative approach to the treatment of several diseases. The current review summarizes the structure, composition, biogenesis, and turnover of lipid droplets, with an emphasis on the factors responsible for the accumulation and importance of lipid droplets in lipodystrophy and neurodegenerative disease.

Abstract Image

脂肪营养不良和神经变性中的脂滴
脂滴是普遍存在但独特的细胞内细胞器,它们在能量储存之外的用途正受到关注。近年来,它们的形成、在生理功能中的作用以及病理发生都受到越来越多的关注。它们的结构、合成和转换在脂肪营养不良和神经变性中都起着动态作用。发育、衰老、炎症和细胞应激等因素调节脂滴的合成。脂滴的生物生成在减轻细胞应激中起着关键作用。脂滴作为应激反应,将有害的脂质隔离到它们的中性脂质核心中,在保护能量和氧化还原平衡的同时防止脂毒性。因此,维持脂肪组织、中枢神经系统和其他身体组织中的脂滴稳态对于维持机体健康至关重要。胰岛素抵抗、高甘油三酯血症和脂滴积聚是伴随脂肪营养不良相关的脂肪缺陷的严重代谢异常。几乎所有的神经退行性疾病,如阿尔茨海默氏症、帕金森氏症、亨廷顿氏症和遗传性痉挛性截瘫,都能检测到脂滴的积聚。因此,调节脂滴可作为治疗多种疾病的替代方法。本文综述了脂滴的结构、组成、生物发生和转化,重点介绍了脂滴积累的因素及其在脂肪营养不良和神经退行性疾病中的重要性。
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来源期刊
Biology of the Cell
Biology of the Cell 生物-细胞生物学
CiteScore
5.30
自引率
0.00%
发文量
53
审稿时长
>12 weeks
期刊介绍: The journal publishes original research articles and reviews on all aspects of cellular, molecular and structural biology, developmental biology, cell physiology and evolution. It will publish articles or reviews contributing to the understanding of the elementary biochemical and biophysical principles of live matter organization from the molecular, cellular and tissues scales and organisms. This includes contributions directed towards understanding biochemical and biophysical mechanisms, structure-function relationships with respect to basic cell and tissue functions, development, development/evolution relationship, morphogenesis, stem cell biology, cell biology of disease, plant cell biology, as well as contributions directed toward understanding integrated processes at the organelles, cell and tissue levels. Contributions using approaches such as high resolution imaging, live imaging, quantitative cell biology and integrated biology; as well as those using innovative genetic and epigenetic technologies, ex-vivo tissue engineering, cellular, tissue and integrated functional analysis, and quantitative biology and modeling to demonstrate original biological principles are encouraged.
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