Harnessing the Ketene Chemistry by Transition-Metal-Catalyzed C−H Functionalization

Abstract

Transition-metal-catalyzed C−H functionalization has become a cornerstone of modern organic synthesis, enabling the efficient formation of various C−C and C-heteroatom bonds. Ketenes, a class of highly reactive and versatile molecules, have recently been harnessed as powerful substrates for C−H functionalization reactions, unlocking new possibilities for the construction of complex molecular frameworks. This review provides a comprehensive overview of the latest advances in transition-metal-catalyzed C−H functionalization with ketenes, encompassing the design of novel catalytic systems, elucidation of reaction mechanisms, and exploration of synthetic applications. By highlighting the current state of the art, challenges, and future prospects, this concept aims to inspire further research and innovation in this rapidly evolving field, ultimately expanding the frontiers of transition-metal-catalyzed C−H functionalization with ketenes.