Electroactive Fe-MOFs as an internal reference for ratiometric electrochemical sensing of 17β-estradiol with reinforcement of graphene nanosheets

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal Pub Date : 2025-04-15 DOI:10.1016/j.microc.2025.113650

Chen Yang , Zhe Zhuang , Xiyu Zhang , Ziyi Ren , Danling Sun , Ping Wu , Jinzhou Liu , Wei Wu , Xuerong Chen

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Abstract

Ratiometric strategy is very effective to improve the reproducibility and reliability of electrochemcial sensors. Herein, a novel internal reference probe namely Fe-based MOFs (MIL-101), was adopted to provide the reference signal due to its obvious Fe oxidation behavior, without the necessary of literatural extensively used fixing electroactive small molecules. Besides, by introducing graphene nanosheet (GS), the resulting MIL-101/GS composite displayed remarkably reinforced electrochemcial active surface, electron transfer kinetics and adsorptive property. Compared to individual components, the composite demonstrated notably improved oxidation signals for both Fe and 17β-estradiol (E2) owing to the combined effects of MIL-101 and GS working together. Based on the dual-signal output model, a sensitive and reliable ratiometric electrochemcial sensor for E2 was readily constructed, possessing a broad linear range of 10–1200 µg L⁻¹ and achieving a low detection limit of 3.55 μg L⁻¹. Finally, good practicability was verified by application of the method in milk sample analysis.

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比率策略对于提高电化学传感器的重现性和可靠性非常有效。本文采用了一种新型内参探针，即铁基 MOFs（MIL-101），由于其具有明显的铁氧化行为，无需使用广泛使用的固定电活性小分子升汞，即可提供参比信号。此外，通过引入石墨烯纳米片（GS），得到的 MIL-101/GS 复合材料在电化学活性表面、电子转移动力学和吸附性能方面都有显著增强。与单个成分相比，由于 MIL-101 和 GS 的共同作用，复合材料对铁和 17β- 雌二醇（E2）的氧化信号都有明显改善。在双信号输出模型的基础上，一种灵敏可靠的 E2 比率电化学传感器被轻松构建出来，其线性范围宽至 10-1200 µg L-1，检测限低至 3.55 μg L-1。最后，该方法在牛奶样品分析中的应用验证了其良好的实用性。

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来源期刊

Microchemical Journal 化学-分析化学

CiteScore

8.70

自引率

8.30%

发文量

1131

审稿时长

1.9 months

期刊介绍： The Microchemical Journal is a peer reviewed journal devoted to all aspects and phases of analytical chemistry and chemical analysis. The Microchemical Journal publishes articles which are at the forefront of modern analytical chemistry and cover innovations in the techniques to the finest possible limits. This includes fundamental aspects, instrumentation, new developments, innovative and novel methods and applications including environmental and clinical field. Traditional classical analytical methods such as spectrophotometry and titrimetry as well as established instrumentation methods such as flame and graphite furnace atomic absorption spectrometry, gas chromatography, and modified glassy or carbon electrode electrochemical methods will be considered, provided they show significant improvements and novelty compared to the established methods.