A different finding on the role of Cerebro-cerebellar RSFC in reading skills among Chinese Children with Developmental Dyslexia

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-04-15 DOI:10.1016/j.jpsychires.2025.04.024

Yuying Jin , Jingxian Zhao , Xintong Su , Si Tan , Xiaojing Song , Kaize Yang , Simin Deng , Lizi Lin , Xiuhong Li

{"title":"A different finding on the role of Cerebro-cerebellar RSFC in reading skills among Chinese Children with Developmental Dyslexia","authors":"Yuying Jin , Jingxian Zhao , Xintong Su , Si Tan , Xiaojing Song , Kaize Yang , Simin Deng , Lizi Lin , Xiuhong Li","doi":"10.1016/j.jpsychires.2025.04.024","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>It’s still unclear on the effect of the cerebellum on developmental dyslexia (DD). To narrow the gap, we compared the cerebro-cerebellar resting-state functional connectivity (RSFC) between children with and without DD, and analyzed the relationship of cerebro-cerebellar RSFC with reading skills.</div></div><div><h3>Methods</h3><div>43 children with DD (32 males, mean age = 9.21 years) and 82 typical development (TD) children (47 males, mean age = 8.96 years) were recruited from China. All participants completed rs-fMRI scan and reading tasks including phonological awareness, rapid automatized naming, and orthography awareness. Cerebro-cerebellar RSFC were compared between children with and without DD. And the correlations between cerebro-cerebellar RSFC and reading skills were analyzed in all subjects.</div></div><div><h3>Results</h3><div>Compared to the TD group, Chinese children with DD showed significantly increased RSFC between cerebellar vermis IX and right superior frontal gyrus, and between cerebellar vermis IX and left middle frontal gyrus. The RSFC between vermis IX and right superior frontal gyrus was correlated with response time of rapid automatized naming (<em>r</em> = 0.198, <em>p</em> = 0.028) and phonological awareness score (<em>r</em> = -0.288, <em>p</em> = 0.002). And the RSFC between vermis IX and left middle frontal gyrus was also correlated with response time of rapid automatized naming (<em>r</em> = 0.223, <em>p</em> = 0.013) and phonological awareness score (<em>r</em> = -0.182, <em>p</em> = 0.048).</div></div><div><h3>Conclusion</h3><div>Chinese children with DD showed increased RSFC between the vermal cerebellum and bilateral frontal gyrus. It may potentially compensate for their phonological awareness and rapid automatized naming deficits.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"186 ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of psychiatric research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022395625002596","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

It’s still unclear on the effect of the cerebellum on developmental dyslexia (DD). To narrow the gap, we compared the cerebro-cerebellar resting-state functional connectivity (RSFC) between children with and without DD, and analyzed the relationship of cerebro-cerebellar RSFC with reading skills.

Methods

43 children with DD (32 males, mean age = 9.21 years) and 82 typical development (TD) children (47 males, mean age = 8.96 years) were recruited from China. All participants completed rs-fMRI scan and reading tasks including phonological awareness, rapid automatized naming, and orthography awareness. Cerebro-cerebellar RSFC were compared between children with and without DD. And the correlations between cerebro-cerebellar RSFC and reading skills were analyzed in all subjects.

Results

Compared to the TD group, Chinese children with DD showed significantly increased RSFC between cerebellar vermis IX and right superior frontal gyrus, and between cerebellar vermis IX and left middle frontal gyrus. The RSFC between vermis IX and right superior frontal gyrus was correlated with response time of rapid automatized naming (r = 0.198, p = 0.028) and phonological awareness score (r = -0.288, p = 0.002). And the RSFC between vermis IX and left middle frontal gyrus was also correlated with response time of rapid automatized naming (r = 0.223, p = 0.013) and phonological awareness score (r = -0.182, p = 0.048).

Conclusion

Chinese children with DD showed increased RSFC between the vermal cerebellum and bilateral frontal gyrus. It may potentially compensate for their phonological awareness and rapid automatized naming deficits.

查看原文本刊更多论文

脑-小脑RSFC在中国发展性阅读障碍儿童阅读技能中的不同作用

背景小脑在发展性阅读障碍（DD）中的作用尚不清楚。为了缩小这一差距，我们比较了患有和未患有DD的儿童的脑小脑静息状态功能连接（RSFC），并分析了脑小脑RSFC与阅读能力的关系。方法选取43例DD患儿（男32例，平均年龄9.21岁）和82例典型发育（TD）患儿（男47例，平均年龄8.96岁）。所有参与者都完成了rs-fMRI扫描和阅读任务，包括语音意识、快速自动命名和拼写意识。比较DD患儿与非DD患儿的脑小脑RSFC，并分析各被试脑小脑RSFC与阅读能力的相关性。结果与TD组相比，中国DD患儿第9小脑蚓部与右侧额上回之间、第9小脑蚓部与左侧额中回之间的RSFC显著升高。第9蚓部与右侧额上回之间的RSFC与快速自动命名反应时间（r = 0.198, p = 0.028）和语音意识评分（r = -0.288, p = 0.002）相关。蚓部与左额中回之间的RSFC与快速自动命名反应时间（r = 0.223, p = 0.013）和语音意识评分（r = -0.182, p = 0.048）也存在相关性。结论中国DD患儿小脑外侧与双侧额回之间的RSFC明显增高。它可能潜在地弥补他们的语音意识和快速自动命名缺陷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;