Correcting uterine cancer mortality in Estonia using linkage of causes of death and cancer registry data, 2000–2021

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2025-04-18 DOI:10.1016/j.canep.2025.102823

Julia Allas , Piret Veerus , Aleksei Baburin , Kaire Innos

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引用次数: 0

Abstract

Background

Cervical and corpus uteri cancer mortality may be underestimated due to a proportion of deaths attributed to unspecified uterine cancer. The aim was to estimate corrected mortality rates and trends for cervical and corpus uteri cancer in Estonia after reallocation of underlying cause of death using individual linkage of death records and cancer registry records.

Methods

Deaths in Estonian female population in 2000–2021 with the underlying cause of cervical cancer (ICD-10 code C53), corpus uteri cancer (C54) or cancer of uterus not otherwise specified (C55) were individually linked to Estonian Cancer Registry to identify any cancers diagnosed in these persons. Underlying cause of death was reallocated if applicable. Original and corrected age-standardized (world) mortality trends were modelled using joinpoint regression.

Results

During 2000–2021, the corrected number of deaths was 1409 cervical cancer deaths (originally 1388, 1.5 % increase), 1146 corpus uteri cancer deaths (902, 27 % increase), and 50 unspecified uterine cancer deaths (368, 86 % decrease). Proportion of unspecified deaths decreased from 26 % (2000–2004) to 4 % (2016–2021) (p < 0.001). After correction, cervical cancer mortality trend steepened slightly from 0.8 % decrease per year to 1.1 % decrease (both significant). Corpus uteri cancer mortality trend changed direction from significant increase of 1.9 % per year to significant decrease of 1.4 % per year.

Conclusions

Routine linkage of causes of death records with cancer registry is warranted for validating underlying cause of death. The results emphasize the importance of the availability of medical documentation for physicians assigning cause of death as well as relevant training.

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利用2000-2021年死亡原因与癌症登记数据的联系，纠正爱沙尼亚的子宫癌死亡率

背景宫颈癌和子宫癌的死亡率可能被低估了，因为有一部分死亡归因于未明确的子宫癌。目的是利用死亡记录和癌症登记记录的个人联系，在重新分配潜在死亡原因后，估计爱沙尼亚宫颈癌和子宫癌的校正死亡率和趋势。方法：2000-2021年期间，爱沙尼亚女性人口中因宫颈癌（ICD-10代码C53）、子宫癌（C54）或未特别指明的子宫癌（C55）的潜在原因死亡的病例分别与爱沙尼亚癌症登记处联系起来，以确定在这些人中诊断出的任何癌症。潜在的死亡原因被重新分配，如果适用的话。原始和校正后的年龄标准化（世界）死亡率趋势采用连接点回归建模。结果2000-2021年期间，修正后的死亡人数为宫颈癌死亡1409人（原1388人，增加1.5% %），子宫癌死亡1146人（增加902人，27% %），未明确的子宫癌死亡50人（减少368,86 %）。未指明死亡比例从26. %（2000-2004年）降至4. %（2016-2021年）（p <； 0.001）。经校正后，子宫颈癌死亡率的趋势由每年下降0.8 %，略微变陡至每年下降1.1 %（两者均有显著意义）。子宫癌死亡率趋势由每年显著上升1.9 %转变为每年显著下降1.4 %。结论将死亡原因记录与癌症登记进行常规联系是验证潜在死亡原因的必要条件。结果强调了医疗文件的可用性对医生分配死亡原因以及相关培训的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.