Metal‐Free Divergent Photocatalytic Cascade [4+2] Addition‐Defluorinative Annulation of gem‐Difluoroalkenes with Terminal Alkynes

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-04-17 DOI:10.1002/adsc.202500314

Dong-Sheng Li, Guang-Xu Zhang, Hao Qian, Fei Xue, Hong-Ping Deng

引用次数: 0

Abstract

A mild, metal‐free protocol for cascade [4+2] addition‐defluorinative annulation of gem‐difluoroalkenes with alkynes was realized via photoredox catalysis. This method was feasible for a wide range of terminal alkynes, affording the 1,3‐cyclohexadiene derivatives or fluoro‐substituted arenes in moderate to good yields, respectively. The merit of this strategy was demonstrated by the late‐stage functionalization of pharmaceuticals and the synthesis of high‐value‐added complex molecules.

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无金属发散光催化级联[4+2]宝石-二氟烯烃与末端炔的加成-去氟环化

通过光氧化还原催化，实现了宝石-二氟烯烃与炔烃的级联[4+2]加成-脱氟环化反应的温和、无金属方案。该方法适用于多种末端炔，分别以中等至较高的产率制备1,3 -环己二烯衍生物或氟取代芳烃。药物后期功能化和高附加值复杂分子的合成证明了这一策略的优点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.