Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease

IF 14.9 1区医学 Q1 NEUROSCIENCES

Molecular Neurodegeneration Pub Date : 2025-04-17 DOI:10.1186/s13024-025-00835-y

Mohammed Zayed, Yong-Chan Kim, Byung-Hoon Jeong

引用次数: 0

Abstract

There is currently no effective therapy for prion diseases. The glymphatic system is an organized system of perivascular spaces that facilitates the removal of metabolic waste from the brain. This study demonstrates the therapeutic potential of a combination therapy of adipose-derived mesenchymal stem cells (AdMSCs) and a glymphatic system-activated drug, clonidine, against prion disease. The therapy has the potential to clear PrPSc accumulation, ameliorate astrocytosis, and prolong the survival time of ME7-infected mice.

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脂肪源性间充质干细胞联合淋巴系统激活治疗朊病毒病的疗效

目前还没有针对朊病毒疾病的有效治疗方法。淋巴系统是一个有组织的血管周围空间系统，有助于从大脑中清除代谢废物。这项研究证明了脂肪源性间充质干细胞（AdMSCs）和淋巴系统激活药物clonidine联合治疗朊病毒疾病的治疗潜力。该疗法有可能清除PrPSc积累，改善星形细胞增生，延长me7感染小鼠的生存时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Neurodegeneration 医学-神经科学

CiteScore

23.00

自引率

4.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Molecular Neurodegeneration, an open-access, peer-reviewed journal, comprehensively covers neurodegeneration research at the molecular and cellular levels. Neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's, and prion diseases, fall under its purview. These disorders, often linked to advanced aging and characterized by varying degrees of dementia, pose a significant public health concern with the growing aging population. Recent strides in understanding the molecular and cellular mechanisms of these neurodegenerative disorders offer valuable insights into their pathogenesis.