Carrier-free co-delivery nanosystem based on prothioconazole and pyrimethanil to enhance fungicidal efficacy and reduce environmental risks

IF 3.8 1区农林科学 Q1 AGRONOMY

Pest Management Science Pub Date : 2025-04-17 DOI:10.1002/ps.8838

Yulu Liu, Yuqi Huang, Gaohua Hu, Gang Tang, Xiaohong Zhang, Weiyao Yan, Jianhua Xiao, Guangyao Yan, Qing Guo, Jiawei Shi, Ruyue Han, Jianqiang Li, Yongsong Cao

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引用次数: 0

Abstract

BACKGROUND

The conventional application of fungicides suffers from substantial off-target loss due to photolysis, evaporation, and rain washing, resulting in risks to the environment and human health. To address these limitations, self-assembled nanopesticides based on two kinds of fungicides have emerged as precision agrochemical delivery platforms that synchronize enhanced bioactivity with environmental risk mitigation.

RESULTS

Herein, core-shell structured nanoparticles (PRO-PYR NPs) with an average particle size of 263 nm were fabricated based on prothioconazole (PRO) and pyrimethanil (PYR) via non-covalent interactions using co-assembly technology. The co-delivery system with acid-responsive release property enhanced both antifungal activities against Botrytis cinerea and Fusarium graminearum and duration against Botrytis cinerea. Importantly, the obtained PRO-PYR NPs could significantly improve photostability and foliage adhesion of fungicides and reduce their volatility and leaching potential. Additionally, the PRO-PYR NPs reduced genotoxicity of PRO and PYR to the root tip cells of Vicia faba and acute toxicity to zebrafish.

CONCLUSION

The core-shell structured nanoparticles based on two commonly used fungicides were successfully prepared by co-assembly technology to effectively improve the physicochemical properties. Carrier-free co-delivery strategy based on multiple components of fungicides could effectively enhance the control effect and lower the negative impacts associated with non-target organisms and environment for integrated pest management. © 2025 Society of Chemical Industry.

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基于prothioconazole和pyrimethanil的无载体共递送纳米系统提高杀真菌效果和降低环境风险

传统的杀菌剂应用由于光解、蒸发和雨水冲刷等原因造成了大量的脱靶损失，给环境和人类健康带来了风险。为了解决这些限制，基于两种杀菌剂的自组装纳米农药已经成为精确的农用化学品输送平台，可以在增强生物活性的同时降低环境风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pest Management Science 农林科学-昆虫学

CiteScore

7.90

自引率

9.80%

发文量

553

审稿时长

4.8 months

期刊介绍： Pest Management Science is the international journal of research and development in crop protection and pest control. Since its launch in 1970, the journal has become the premier forum for papers on the discovery, application, and impact on the environment of products and strategies designed for pest management. Published for SCI by John Wiley & Sons Ltd.